Biological Treatments in Atopic Dermatitis

被引：49

作者：

Montes-Torres, Andrea ^{[1
]}

Llamas-Velasco, Mar ^{[1
]}

Perez-Plaza, Alejandra ^{[1
]}

Solano-Lopez, Guillermo ^{[1
]}

Sanchez-Perez, Javier ^{[1
]}

机构：

[1] Hosp Univ La Princesa, Dept Dermatol, Diego de Leon 62, Madrid 28006, Spain

来源：

JOURNAL OF CLINICAL MEDICINE | 2015年 / 4卷 / 04期

关键词：

atopic eczema; atopic dermatitis; pathogenesis; biologics; antibody therapy; ANTI-CD20 RITUXIMAB TREATMENT; MONOCLONAL-ANTIBODY; T-CELLS; MAST-CELLS; ECZEMA; OMALIZUMAB; THERAPY; RECEPTOR; EFALIZUMAB; ADULT;

D O I：

10.3390/jcm4040593

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Atopic dermatitis (AD) is one of the most common chronic inflammatory skin diseases that affect both children and adults with a prevalence of 30% and 10%, respectively. Even though most of patients respond satisfactory to topical anti-inflammatory drugs, about 10% require one or more systemic treatments to achieve good control of their illness. The progressive and increasingly detailed knowledge in the immunopathogenesis of AD has allowed research on new therapeutic targets with very promising results in the field of biological therapy. In this article, we will review the different biological treatments with a focus on novel drugs. Their mechanism of action, current status and results from clinical trials and observational studies will be specified.

引用

页码：593 / 613

页数：21

共 102 条

[1] Role of Interleukin 1 in Atopic Dermatitis [J].

Abramovits, William ;

Bejarano, Joaquin J. Rivas ;

Valdecantos, Wendell C. .

DERMATOLOGIC CLINICS, 2013, 31 (03) :437-+

[2] Severe Refractory Atopic Dermatitis in an Adolescent Patient Successfully Treated with Ustekinumab [J].

Agusti-Mejias, Anna ;

Messeguer, Francesc ;

Garcia, Ramon ;

Febrer, Isabel .

ANNALS OF DERMATOLOGY, 2013, 25 (03) :368-370

[3]

Antoniu SA, 2010, CURR OPIN INVEST DR, V11, P1286

[4] Pharmacokinetics, pharmacodynamics and safety of QGE031 (ligelizumab), a novel high-affinity anti-IgE antibody, in atopic subjects [J].

Arm, J. P. ;

Bottoli, I. ;

Skerjanec, A. ;

Floch, D. ;

Groenewegen, A. ;

Maahs, S. ;

Owen, C. E. ;

Jones, I. ;

Lowe, P. J. .

CLINICAL AND EXPERIMENTAL ALLERGY, 2014, 44 (11) :1371-1385

[5] Cytokines and T cells in atopic dermatitis [J].

Auriemma, Matteo ;

Vianale, Giovina ;

Amerio, Paolo ;

Reale, Marcella .

EUROPEAN CYTOKINE NETWORK, 2013, 24 (01) :37-44

[6] Clinical Outcomes in Patients With Psoriasis Following Discontinuation of Efalizumab due to Suspension of Marketing Authorization [J].

Baniandres, O. ;

Pulido, A. ;

Silvente, C. ;

Suarez, R. ;

Lazaro, P. .

ACTAS DERMO-SIFILIOGRAFICAS, 2010, 101 (05) :421-427

[7] Profile of skin barrier proteins (filaggrin, claudins 1 and 4) and Th1/Th2/Th17 cytokines in adults with atopic dermatitis [J].

Batista, D. I. S. ;

Perez, L. ;

Orfali, R. L. ;

Zaniboni, M. C. ;

Samorano, L. P. ;

Pereira, N. V. ;

Sotto, M. N. ;

Ishizaki, A. S. ;

Oliveira, L. M. S. ;

Sato, M. N. ;

Aoki, V. .

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY, 2015, 29 (06) :1091-1095

[8] Dupilumab Treatment in Adults with Moderate-to-Severe Atopic Dermatitis [J].

Beck, Lisa A. ;

Thaci, Diamant ;

Hamilton, Jennifer D. ;

Graham, Neil M. ;

Bieber, Thomas ;

Rocklin, Ross ;

Ming, Jeffrey E. ;

Ren, Haobo ;

Kao, Richard ;

Simpson, Eric ;

Ardeleanu, Marius ;

Weinstein, Steven P. ;

Pirozzi, Gianluca ;

Guttman-Yassky, Emma ;

Suarez-Farinas, Mayte ;

Hager, Melissa D. ;

Stahl, Neil ;

Yancopoulos, George D. ;

Radin, Allen R. .

NEW ENGLAND JOURNAL OF MEDICINE, 2014, 371 (02) :130-139

[9] Novel immunological approaches in the treatment of atopic eczema [J].

Belloni, Benedetta ;

Andres, Christian ;

Ollert, Markus ;

Ring, Johannes ;

Mempel, Martin .

CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY, 2008, 8 (05) :423-427

[10] Low-dose anti-IgE therapy in patients with atopic eczema with high serum IgE levels [J].

Belloni, Benedetta ;

Ziai, Mahzad ;

Lim, Annick ;

Lemercier, Brigitte ;

Sbornik, Martin ;

Weidinger, Stephan ;

Andres, Christian ;

Schnopp, Christina ;

Ring, Johannes ;

Hein, Ruediger ;

Ollert, Markus ;

Mempel, Martin .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2007, 120 (05) :1223-1225

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