Systemic Protein Therapy for Recessive Dystrophic Epidermolysis Bullosa: How Far Are We from Clinical Translation?

被引：11
作者：
Hovnanian, Alain [1 ,2 ,3 ]
机构：
[1] Univ Paris Descartes Sorbonne Paris Cite, Imagine Inst, Paris, France
[2] INSERM, U781, Paris, France
[3] Hop Necker Enfants Malad, Dept Genet, Paris, France
来源：
JOURNAL OF INVESTIGATIVE DERMATOLOGY | 2013年 / 133卷 / 07期
关键词：
VII COLLAGEN; GENE-THERAPY; TRANSPLANTATION; INJECTION;
D O I：
10.1038/jid.2013.137
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
In this issue, Wood ley et al. report restoration of anchoring fibril formation and dermal-epidermal adherence in a murine model of recessive dystrophic epidermolysis bullosa (RDEB) by intravenous injection of recombinant human type VII collagen. This work follows a previous report by the same group of the surprising capability of intradermally injected type VII collagen protein to reverse RDEB, and it opens new therapeutic avenues.
引用
收藏
页码：1719 / 1721
页数：3
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