Design, synthesis and biological evaluation of novel indano- and thiaindano-pyrazoles with potential interest for Alzheimer's disease

被引：25
作者：
Genest, David [1 ,2 ]
Rochais, Christophe [1 ,2 ]
Lecoutey, Cedric [1 ,2 ]
Santos, Jana Sopkova-de Oliveira [1 ,2 ]
Ballandonne, Celine [1 ,2 ]
Butt-Gueulle, Sabrina [1 ,2 ]
Legay, Remi [1 ,2 ]
Since, Marc [1 ,2 ]
Dallemagne, Patrick [1 ,2 ]
机构：
[1] Normandie Univ, Caen, France
[2] Univ Caen Basse Normandie, Ctr Etud & Rech Med Normandie, EA FR CNRS SF ICORE INC3M 4258 3038 4206, UFR Sci Pharmaceut, F-14032 Caen, France
来源：
MEDCHEMCOMM | 2013年 / 4卷 / 06期
关键词：
SITE ACETYLCHOLINESTERASE INHIBITORS; TARGET-DIRECTED LIGANDS; GENETIC ALGORITHM; MODIFYING AGENTS; ACHE INHIBITORS; DUAL INHIBITORS; PERIPHERAL SITE; AMMONIUM-SALTS; HIGHLY POTENT; DERIVATIVES;
D O I：
10.1039/c3md00041a
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The synthesis of eighteen novel (thia)indanopyrazole derivatives was achieved starting from amino(thia)indanones. Some of them displayed a dual binding site acetylcholinesterase inhibition which makes them potentially interesting for Alzheimer's disease treatment.
引用
收藏
页码：925 / 931
页数：7
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