Sulfonopeptide inhibitors of leukocyte adhesion

被引：48
作者：
Carson, KG
Schwender, CF
Shroff, HN
Cochran, NA
Gallant, DL
Briskin, MJ
机构：
[1] LeukoSite, Inc., Cambridge, MA 02142
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1997年 / 7卷 / 06期
关键词：
D O I：
10.1016/S0960-894X(97)00090-5
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The amino acid sequence L-D-T-S-L has been shown to be a significant recognition motif involved in the interaction of integrin alpha(4) beta(7) with its endothelial ligand, MAdCAM-1. Based on the known active peptide, a series of sulfonamide peptidomimetics was synthesized. Sulfonopeptide 2, Ac-L-Psi D-V-NH2, was shown to inhibit leukocyte adhesion. (C) 1997 Elsevier Science Ltd.
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收藏
页码：711 / 714
页数：4
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