Sulfonopeptide inhibitors of leukocyte adhesion

被引：48

作者：

Carson, KG

Schwender, CF

Shroff, HN

Cochran, NA

Gallant, DL

Briskin, MJ

机构：

[1] LeukoSite, Inc., Cambridge, MA 02142

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1997年 / 7卷 / 06期

关键词：

D O I：

10.1016/S0960-894X(97)00090-5

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The amino acid sequence L-D-T-S-L has been shown to be a significant recognition motif involved in the interaction of integrin alpha(4) beta(7) with its endothelial ligand, MAdCAM-1. Based on the known active peptide, a series of sulfonamide peptidomimetics was synthesized. Sulfonopeptide 2, Ac-L-Psi D-V-NH2, was shown to inhibit leukocyte adhesion. (C) 1997 Elsevier Science Ltd.

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页码：711 / 714

页数：4

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