Adverse effects on insulin secretion of replacing saturated fat with refined carbohydrate but not with monounsaturated fat: A randomized controlled trial in centrally obese subjects

被引:10
作者
Chang, Lin F. [1 ,2 ]
Vethakkan, Shireene R. [1 ]
Nesaretnam, Kalanithi [2 ]
Sanders, Thomas A. B. [3 ]
Teng, Kim-Tiu [2 ]
机构
[1] Univ Malaya, Dept Med, Fac Med, Kuala Lumpur, Malaysia
[2] MPOB, Prod Dev & Advisory Serv Div, Kajang, Selangor, Malaysia
[3] Kings Coll London, Diabet & Nutr Sci Div, Sch Med, London, England
关键词
Abdominal obesity; Central obesity; Saturated fatty acids; Carbohydrates; Monounsaturated fatty acids; Type; 2; diabetes; Insulin secretion; Insulin sensitivity; Gastrointestinal peptide; Gut hormone; GASTRIC-INHIBITORY POLYPEPTIDE; BETA-CELL FUNCTION; POSTPRANDIAL LIPEMIA; METABOLIC SYNDROME; GLUCOSE-TOLERANCE; INCRETIN ACTIONS; PLASMA-GLUCOSE; SN-2; POSITION; PALMITIC ACID; ORAL GLUCOSE;
D O I
10.1016/j.jacl.2016.09.006
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
BACKGROUND: Current dietary guidelines recommend the replacement of saturated fatty acids (SAFAs) with carbohydrates or monounsaturated fatty acids (MUFAs) based on evidence on lipid profile alone, the chronic effects of the mentioned replacements on insulin secretion and insulin sensitivity are however unclear. OBJECTIVE: To assess the chronic effects of the substitution of refined carbohydrate or MUFA for SAFA on insulin secretion and insulin sensitivity in centrally obese subjects. METHODS: Using a crossover design, randomized controlled trial in abdominally overweight men and women, we compared the effects of substitution of 7% energy as carbohydrate or MUFA for SAFA for a period of 6 weeks each. Fasting and postprandial blood samples in response to corresponding SAFA, carbohydrate, or MUFA-enriched meal-challenges were collected after 6 weeks on each diet treatment for the assessment of outcomes. RESULTS: As expected, postprandial nonesterified fatty acid suppression and elevation of C-peptide, insulin and glucose secretion were the greatest with high-carbohydrate (CARE) meal. Interestingly, CARB meal attenuated postprandial insulin secretion corrected for glucose response; however, the insulin sensitivity and disposition index were not affected. SAFA and MUFA had similar effects on all markers except for fasting glucose-dependent insulinotropic peptide concentrations, which increased after MUFA but not SAFA when compared with CARB. CONCLUSION: In conclusion, a 6-week lower-fat/higher-carbohydrate (increased by 7% refined carbohydrate) diet may have greater adverse effect on insulin secretion corrected for glucose compared with isocaloric higher-fat diets. In contrast, exchanging MUFA for SAFA at 7% energy had no appreciable adverse impact on insulin secretion. (C) 2016 National Lipid Association. Published by Elsevier Inc.
引用
收藏
页码:1431 / 1441
页数:11
相关论文
共 50 条
[1]   Reduced gastric inhibitory polypeptide but normal glucagon-like peptide 1 response to oral glucose in postmenopausal women with impaired glucose tolerance [J].
Ahren, B ;
Larsson, H ;
Holst, JJ .
EUROPEAN JOURNAL OF ENDOCRINOLOGY, 1997, 137 (02) :127-131
[2]  
[Anonymous], 2010, FAO Food Nutr Pap, V91, P1
[3]  
[Anonymous], 1998, FAO Food Nutr Pap, V66, P1
[4]  
[Anonymous], LANCET
[5]  
[Anonymous], INT J PEPT
[6]   Too much of a good thing: why it is bad to stimulate the beta cell to secrete insulin [J].
Aston-Mourney, K. ;
Proietto, J. ;
Morahan, G. ;
Andrikopoulos, S. .
DIABETOLOGIA, 2008, 51 (04) :540-545
[7]   International Tables of Glycemic Index and Glycemic Load Values: 2008 [J].
Atkinson, Fiona S. ;
Foster-Powell, Kaye ;
Brand-Miller, Jennie C. .
DIABETES CARE, 2008, 31 (12) :2281-2283
[8]   Obesity, adiposity, and dyslipidemia: A consensus statement from the National Lipid Association [J].
Bays, Harold E. ;
Toth, Peter P. ;
Kris-Etherton, Penny M. ;
Abate, Nicola ;
Aronne, Louis J. ;
Brown, W. Virgil ;
Gonzalez-Campoy, J. Michael ;
Jones, Steven R. ;
Kumar, Rekha ;
La Forge, Ralph ;
Samuel, Varman T. .
JOURNAL OF CLINICAL LIPIDOLOGY, 2013, 7 (04) :304-383
[9]   Associations Between Macronutrient Intake and Self-reported Appetite and Fasting Levels of Appetite Hormones: Results From the Optimal Macronutrient Intake Trial to Prevent Heart Disease [J].
Beasley, Jeannette M. ;
Ange, Brett A. ;
Anderson, Cheryl A. M. ;
Miller, Edgar R., III ;
Erlinger, Thomas P. ;
Holbrook, Janet T. ;
Sacks, Frank M. ;
Appel, Lawrence J. .
AMERICAN JOURNAL OF EPIDEMIOLOGY, 2009, 169 (07) :893-900
[10]   A practical guide for the stabilization of acylghrelin in human blood collections [J].
Blatnik, Matthew ;
Soderstrom, Catherine I. .
CLINICAL ENDOCRINOLOGY, 2011, 74 (03) :325-331