QSAR study of N-[3-(1,1,2,2-tetrafluoroethoxy)benzyl]-N-(3-phenoxyphenyl)trifluoro-3-amino-2-propanol derivatives as antiatherogenic agents

被引：0
|
作者：
Singh, Hemendra Pratap [1 ]
Nema, R. K. [1 ]
Singh, Anoop [1 ]
Gupta, Sayan D. [1 ]
机构：
[1] BN Coll Pharm, Dept Pharmaceut Chem, Udaipur 313001, India
来源：
ASIAN JOURNAL OF CHEMISTRY | 2008年 / 20卷 / 01期
关键词：
QSAR; antiatherogenic agents; coronary heart disease; Cholesterol ester transfer protein; descriptors;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Coronary heart disease is one of the dreaded diseases prevailing now a day, which can be treated by the use of more potent and selective agents. One of such agent is Cholesterol ester transfer protein inhibitors. N-[3-(1,1,2,2-tetrafluoroethoxy)benzyl]-N-(3-phenoxyphenyl)trifluoro-3-amino-2-propanol derivatives has screened as antiatherogenic agents. So, N-[3-(1,1,2,2-tetrafluoroethoxy)benzyl]-N-(3-phenoxyphenyl)trifluoro-3-amino-2-propanol derivatives were selected for quantitative structure activity relationships, for the present study. QSAR studies with significant equations indicate that the molar refractivity in the R-3 position of the parent compound negatively contributed for activity.
引用
收藏
页码：591 / 594
页数：4
相关论文
共 50 条
  • [41] SAR study of a subtype selective allosteric potentiator of metabotropic glutamate 2 receptor, N-(4-phenoxyphenyl) N-(3-pyridinylmethyl)ethanesulfonamide
    Barda, DA
    Wang, ZQ
    Britton, TC
    Henry, SS
    Jagdmann, GE
    Coleman, DS
    Johnson, MP
    Andis, SL
    Schoepp, DD
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2004, 14 (12) : 3099 - 3102
  • [42] N-{3-[3-(2,2-dimethylpropionyl)thioureido] propyl}-2,2-dimethylpropionamide
    Yusof, M. Sukeri M.
    Ayob, Noor Adila Che
    Yamin, Bohari M.
    ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS, 2007, 63 : O4860 - U6476
  • [43] REACTION OF N,N-DISUBSTITUTED ALPHA-AMINOMETHYLENEKETONES WITH TOSYL ISOCYANATE - SYNTHESIS OF AMINO-DISUBSTITUTED "2-ACYL-3-AMINO-N-TOSYLPROPENAMIDES, N,N-(3-AMINO-1-ALKYL-2-PROPENYLIDENE) AND N,N-[2-(AMINOMETHYLENE)CYCLOHEXYLIDENE]TOSYLAMIDES
    ROMUSSI, G
    PARODI, B
    BIGNARDI, G
    MENOZZI, G
    SCHENONE, P
    FARMACO-EDIZIONE SCIENTIFICA, 1986, 41 (07): : 539 - 547
  • [44] N-[3-(1-ALKYLPIPERIDYL)]ACETAMIDES AND N,N-DIMETHYL-N'-[3-(1-ALKYLPIPERIDYL)]UREAS AS CHOLINESTERASE INHIBITORS .I.
    MATHISON, IW
    BEASLEY, JG
    FOWLER, KC
    PETERS, ER
    JOURNAL OF MEDICINAL CHEMISTRY, 1969, 12 (05) : 928 - &
  • [45] N-{(1Z)-1-[(6-Chloropyridin-3-ylmethyl)(ethyl)amino]-3-(3-chlorophenyl)-2-nitro5-oxohex-1-enyl}-N-methylacetamide
    Sun, Chuan-Wen
    Wu, Ying
    Wang, Jing
    ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS, 2012, 68 : O3229 - +
  • [46] SYNTHESIS OF N-(5-AMINOPYRAZOL-3-YL)AMINO AND N-(5-AMINO-1,2,4-TRIAZOL-3-YL)AMINO ACIDS
    YOKOYAMA, M
    KUMATA, K
    NORO, H
    KOGO, A
    SYNTHESIS-STUTTGART, 1988, (07): : 553 - 555
  • [47] SYNTHESIS AND ANTIBACTERIAL EVALUATION OF N-(AZETIDIN-2-ON-1-YL)/N-(THIAZOLIDIN-3-ON-1-YL) CARBAMOYLCOUMARINS
    Jeyachandran, M.
    Ramesh, P.
    INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY, 2009, 19 (02) : 195 - 196
  • [48] Benzyl N-[(Z)-(1-methyl-2-sulfanyl-propylidene)amino]carbamodithioate
    bin Break, Mohammed Khaled
    Mehta, Sachin
    Tahir, M. Ibrahim M.
    Crouse, Karen A.
    Khoo, Teng-Jin
    ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS, 2013, 69 : O178 - +
  • [49] ANTISPASMODICS - N-(3-PHENYLPROPYL)-AMINES AND 3-AMINO-1-PHENYL-1-PROPANOLS
    RUDDY, AW
    BUCKLEY, JS
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1950, 72 (02) : 718 - 724
  • [50] SYNTHESIS OF N-(3-AMINO-2-HYDROXY PROPYL)-N-SULFONYLANILINES DERIVATIVES - ANTIANGINE ACTIVITIES
    GOLDENBERG, C
    VANMEERBEECK, C
    WANDESTRICK, R
    DESCAMPS, M
    TORNAY, C
    DIRKS, M
    COLOT, M
    DECLAVIERE, M
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 1980, 15 (06) : 545 - 550
12345