Generation of myo-inositol-auxotrophic Leishmania mexicana mutants by targeted replacement of the myo-inositol-1-phosphate synthase gene

被引：32
|
作者：
Ilg, T [1 ]
机构：
[1] Max Planck Inst Biol, Abt Membranbiochem, D-72076 Tubingen, Germany
来源：
MOLECULAR AND BIOCHEMICAL PARASITOLOGY | 2002年 / 120卷 / 01期
关键词：
Leishmania; myo-inositol-1-phosphate synthase; targeted gene deletion; myo-inositol auxotrophy; virulence; glycosylphosphatidylinositol;
D O I：
10.1016/S0166-6851(01)00435-2
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
[No abstract available]
引用
收藏
页码：151 / 156
页数：6
相关论文
共 50 条
  • [1] STEREOCHEMISTRY OF THE MYO-INOSITOL-1-PHOSPHATE SYNTHASE REACTION
    LOEWUS, MW
    LOEWUS, FA
    BRILLINGER, GU
    OTSUKA, H
    FLOSS, HG
    JOURNAL OF BIOLOGICAL CHEMISTRY, 1980, 255 (24) : 1710 - 1712
  • [2] The myo-inositol-1-phosphate synthase gene is essential in Tryponosoma brucei
    Martin, KL
    Smith, TK
    BIOCHEMICAL SOCIETY TRANSACTIONS, 2005, 33 : 983 - 985
  • [3] Valproate is an inhibitor of myo-inositol-1-phosphate synthase
    Agam, G
    Shaltiel, G
    Shamir, A
    Shapiro, J
    Ding, D
    Dalton, E
    Bialer, M
    Harwood, AJ
    Belmaker, RH
    Greenberg, ML
    INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 2004, 7 : S124 - S124
  • [4] ENANTIOMERIC FORM OF MYO-INOSITOL-1-PHOSPHATE PRODUCED BY MYO-INOSITOL-1-PHOSPHATE SYNTHASE AND MYOINOSITOL KINASE IN HIGHER-PLANTS
    LOEWUS, MW
    SASAKI, K
    LEAVITT, AL
    MUNSELL, L
    SHERMAN, WR
    LOEWUS, FA
    PLANT PHYSIOLOGY, 1982, 70 (06) : 1661 - 1663
  • [5] Valproate inhibits myo-inositol-1-phosphate (MIP) synthase
    Agam, G
    Shaltiel, G
    Shamir, A
    Belmaker, RH
    Harwood, A
    Greenberg, M
    NEUROPSYCHOPHARMACOLOGY, 2004, 29 : S86 - S86
  • [6] Molecular characterization of Drosophila melanogaster myo-inositol-1-phosphate synthase
    Park, D
    Jeong, S
    Lee, S
    Park, S
    Kim, JI
    Yim, J
    BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION, 2000, 1494 (03): : 277 - 281
  • [7] INHIBITION OF MYO-INOSITOL-1-PHOSPHATE SYNTHASE BY A REACTION COORDINATE INTERMEDIATE
    MIGAUD, ME
    FROST, JW
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1995, 117 (18) : 5154 - 5155
  • [8] ACTIVITY OF MYO-INOSITOL-1-PHOSPHATE SYNTHASE IN THE EPIDIDYMAL SPERMATOZOA OF RAMS
    LOEWUS, MW
    WRIGHT, RW
    BONDIOLI, KR
    BEDGAR, DL
    KARL, A
    JOURNAL OF REPRODUCTION AND FERTILITY, 1983, 69 (01): : 215 - 220
  • [9] Biosynthesis of myo-inositol in Escherichia coli by engineering myo-inositol-1-phosphate pathway
    Yi, Minghua
    Yang, Liuzhen
    Ma, Jian
    Liu, Hang
    He, Min
    Hu, Chunyu
    Yu, Ping
    BIOCHEMICAL ENGINEERING JOURNAL, 2020, 164
  • [10] Biosynthesis of myo-inositol in lycopods: characteristics of the pteridophytic l-myo-inositol-1-phosphate synthase and myo-inositol-1-phosphate phosphatase from the strobili of Lycopodium clavatum and Selaginella monospora
    Anusuya Basak
    Timir Baran Jha
    Jukta Adhikari
    Acta Physiologiae Plantarum, 2012, 34 : 1579 - 1582
12345