Brain-derived neurotrophic factor-induced potentiation of glutamate and GABA release: Different dependency on signaling pathways and neuronal activity

被引:77
作者
Matsumoto, T
Numakawa, T
Yokomaku, D
Adachi, N
Yamagishi, S
Numakawa, Y
Kunugi, H
Taguchi, T
机构
[1] Natl Ctr Neurol & Psychiat, Natl Inst Neurosci, Dept Mental Disorder Res, Tokyo 1878502, Japan
[2] Natl Inst Adv Ind Sci & Technol, Res Inst Cell Engn, Neuron Res Grp, Osaka 5638577, Japan
[3] Osaka Univ, Inst Prot Res, Div Prot Biosynth, Suita, Osaka 5650871, Japan
关键词
D O I
10.1016/j.mcn.2005.09.002
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The mechanisms underlying BDNF-modulated neurotransmitter release remain elusive. Here, we found that 24-h exposure of postnatal cortical neurons to BDNF potentiated depolarization-evoked glutamate and GABA release in a protein synthesis-dependent manner. BDNFpotentiated glutamate release occurred through the PLC-gamma and MAPK pathways. The expression of synapsin I, synaptotagmin, and synaptophysin, but not of syntaxin or SNAP25, increased through the PLC-gamma and MAPK pathways. In contrast, BDNF-up-regulated GABA release and GAD65/67 expression depended on MAPK. Furthermore, neuronal activity was necessary for the up-regulation of glutamate release and synapsin I, synaptotagmin, and synaptophysin expression, but not of GABA or GAD65/67. PLC-gamma inhibitor attenuated BDNF-stimulated long-lasting MAPK activation. As BDNF rapidly potentiates glutamatergic transmission through PLC-gamma (J. BioL Client. 277, (2002) 6520-6529), PLC-gamma-mediated neuronal activity might sustain MAPK activation, resulting in BDNF-potentiated glutamate release. In conclusion, BDNF potentiates the excitatory and inhibitory system separately, which may be important for the regulation of synaptic plasticity. (C) 2005 Elsevier Inc. All rights reserved.
引用
收藏
页码:70 / 84
页数:15
相关论文
共 54 条
  • [1] ERK1/2 activation is necessary for BDNF to increase dendritic spine density in hippocampal CA1 pyramidal neurons
    Alonso, M
    Medina, JH
    Pozzo-Miller, L
    [J]. LEARNING & MEMORY, 2004, 11 (02) : 172 - 178
  • [2] BERG MM, 1992, J BIOL CHEM, V267, P13
  • [3] Neurotrophins: key regulators of cell fate and cell shape in the vertebrate nervous system
    Bibel, M
    Barde, YA
    [J]. GENES & DEVELOPMENT, 2000, 14 (23) : 2919 - 2937
  • [4] BDNF reduces miniature inhibitory postsynaptic currents by rapid downregulation of GABAA receptor surface expression
    Brünig, I
    Penschuck, S
    Berninger, B
    Benson, J
    Fritschy, JM
    [J]. EUROPEAN JOURNAL OF NEUROSCIENCE, 2001, 13 (07) : 1320 - 1328
  • [5] Regulated secretion of neurotrophins by metabotropic glutamate group I (mGluRI) and Trk receptor activation is mediated via phospholipase C signalling pathways
    Canossa, M
    Gärtner, A
    Campana, G
    Inagaki, N
    Thoenen, H
    [J]. EMBO JOURNAL, 2001, 20 (07) : 1640 - 1650
  • [6] N-methyl D-aspartate receptor-mediated bidirectional control of extracellular signal-regulated kinase activity in cortical neuronal cultures
    Chandler, LJ
    Sutton, G
    Dorairaj, NR
    Norwood, D
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (04) : 2627 - 2636
  • [7] Identification of a novel inhibitor of mitogen-activated protein kinase kinase
    Favata, MF
    Horiuchi, KY
    Manos, EJ
    Daulerio, AJ
    Stradley, DA
    Feeser, WS
    Van Dyk, DE
    Pitts, WJ
    Earl, RA
    Hobbs, F
    Copeland, RA
    Magolda, RL
    Scherle, PA
    Trzaskos, JM
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (29) : 18623 - 18632
  • [8] Gottschalk WA, 1999, LEARN MEMORY, V6, P243
  • [9] RE-EXAMINATION AND FURTHER DEVELOPMENT OF A PRECISE AND RAPID DYE METHOD FOR MEASURING CELL-GROWTH CELL KILL
    HANSEN, MB
    NIELSEN, SE
    BERG, K
    [J]. JOURNAL OF IMMUNOLOGICAL METHODS, 1989, 119 (02) : 203 - 210
  • [10] Trk receptors: Roles in neuronal signal transduction
    Huang, EJ
    Reichardt, LF
    [J]. ANNUAL REVIEW OF BIOCHEMISTRY, 2003, 72 : 609 - 642