Cancer Cell Cytotoxicity of Cyclometalated Compounds Obtained with Osmium(II) Complexes

被引：48

作者：

Boff, Bastien ^{[1
]}

Gaiddon, Christian ^{[2
]}

Pfeffer, Michel ^{[1
]}

机构：

[1] Univ Strasbourg, CNRS, Inst Chim, UMR 7177, F-67000 Strasbourg, France

[2] INSERM, U682, F-67200 Strasbourg, France

来源：

INORGANIC CHEMISTRY | 2013年 / 52卷 / 05期

关键词：

PLATINUM(II) COMPLEXES; ANTITUMOR-ACTIVITY; ARENE COMPLEXES; CYCLOPALLADATED COMPLEXES; ORGANOGOLD(III) COMPOUNDS; LIQUID-CHROMATOGRAPHY; ANTICANCER AGENTS; RUTHENIUM; LIGANDS; DNA;

D O I：

10.1021/ic302779q

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A library of 29 organoosmium compounds has been built up with known and novel cyclometalated compounds obtained with C-N, N boolean AND C boolean AND N, and C boolean AND N boolean AND N ligands. All compounds have been tested for their in vitro cytotoxic properties against A172, a tumor cell line derived from a human glioblastoma, this affording a contrasted picture of the activities of the compounds gathered in this study. Some compounds displayed good to excellent activities, some of them showing IC50 in the nanomolar range. The level of activity was tentatively correlated to several physicochemical properties of the compounds such as their E-1/2(0)(Os-III/II) redox potential and their lipophilicity (log P-o/w). A parallel with related ruthenium derivatives was tentatively proposed.

引用

页码：2705 / 2715

页数：11

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