Regulatory T and B cells in peripheral blood of subcutaneous immunotherapy-treated Japanese cedar pollinosis patients

被引：11

作者：

Matsuda, Masaya ^{[1
]}

Terada, Tetsuya ^{[2
]}

Tsujimoto, Nau ^{[1
]}

Morie, Yuki ^{[1
]}

Ishida, Tomoki ^{[1
]}

Takahashi, Hiromu ^{[1
]}

Hamaguchi, Junpei ^{[1
]}

Tabuchi, Yuki ^{[1
]}

Doi, Kana ^{[1
]}

Noro, Keiki ^{[2
]}

Kikuoka, Yusuke ^{[2
]}

Omura, Shuji ^{[2
]}

Yoshida, Takuya ^{[2
]}

Ayani, Yusuke ^{[2
]}

Suzuki, Manabu ^{[2
]}

Ichihara, Takahiro ^{[2
]}

Inaka, Yuko ^{[2
]}

Inui, Takaki ^{[2
]}

Kawata, Ryo ^{[2
]}

Nabe, Takeshi ^{[1
]}

机构：

[1] Setsunan Univ, Fac Pharmaceut Sci, Lab Immunopharmacol, Hirakata, Osaka, Japan

[2] Osaka Med Coll, Dept Otolaryngol Head & Neck Surg, Takatsuki, Osaka, Japan

来源：

IMMUNOTHERAPY | 2019年 / 11卷 / 06期

关键词：

allergies; cellular immunology; clinical immunology; immunological markers; immunotherapy; ALLERGEN-SPECIFIC IMMUNOTHERAPY; DUST MITE IMMUNOTHERAPY; TRANSCRIPTION FACTOR; IL-10; PRODUCTION; CLINICAL-EFFICACY; IMMUNE-RESPONSES; MECHANISMS; INDUCTION; TOLERANCE; ASTHMA;

D O I：

10.2217/imt-2018-0170

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Aim: The aim of this study was to clarify whether there are more regulatory T (Treg) and regulatory B (Breg) cells, and higher levels of IL-10-related transcription factors in subcutaneous immunotherapy (SCIT)-treated pollinosis patients than in non-SCIT-treated patients. Methods: Japanese cedar pollinosis patients undergoing SCIT had received treatment for at least 2.8 years. Peripheral blood mononuclear cells were used for flow cytometer analyses and mRNA measurement. Results: The numbers of type 1 regulatory T (Tr1)-like cells and Breg cells, and expression of E4BP4 mRNA by peripheral blood mononuclear cells in SCIT-treated patients were higher than those in non-SCIT-treated patients. Conclusion: Tr1-like cells, Breg cells and E4BP4 may be involved in the effectiveness of SCIT.

引用

收藏

页码：473 / 482

页数：10

相关论文

共 50 条

[41] The Proportion of Regulatory T Cells in the Peripheral Blood Reflects the Relapse or Remission Status of Patients with Churg-Strauss Syndrome [J].

Saito, Hiroshi ;

Tsurikisawa, Naomi ;

Tsuburai, Takahiro ;

Oshikata, Chiyako ;

Akiyama, Kazuo .

INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, 2011, 155 :46-52

[42] Regulatory T-cells are possible effect prediction markers of immunotherapy for cancer patients [J].

Wada, Junji ;

Yamasaki, Akio ;

Nagai, Shuntaro ;

Yanai, Kousuke ;

Fuchino, Kouta ;

Kameda, Chizu ;

Tanaka, Haruo ;

Koga, Kenichiro ;

Nakashima, Hiroshi ;

Nakamura, Masafumi ;

Tanaka, Masao ;

Katano, Mitsuo ;

Morisaki, Takashi .

ANTICANCER RESEARCH, 2008, 28 (4C) :2401-2408

[43] Altered chromatin landscape in circulating T follicular helper and regulatory cells following grass pollen subcutaneous and sublingual immunotherapy [J].

Sharif, Hanisah ;

Acharya, Swati ;

Dhondalay, Gopal Krishna R. ;

Varricchi, Gilda ;

Krasner-Macleod, Shoshanna ;

Laisuan, Wannada ;

Switzer, Amy ;

Lenormand, Madison ;

Kashe, Elena ;

Parkin, Rebecca, V ;

Yi, Yi ;

Koc, Merve ;

Fedina, Oleksandra ;

Vila-Nadal, Gemma ;

Marone, Gianni ;

Eifan, Aarif ;

Scadding, Guy W. ;

Fear, David J. ;

Nadeau, Kari C. ;

Durham, Stephen R. ;

Shamji, Mohamed H. .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2021, 147 (02) :663-676

[44] Peripheral blood CD4+ CD25+ CD127low regulatory T cells are significantly increased by tocilizumab treatment in patients with rheumatoid arthritis: increase in regulatory T cells correlates with clinical response [J].

Kikuchi, Jun ;

Hashizume, Misato ;

Kaneko, Yuko ;

Yoshimoto, Keiko ;

Nishina, Naoshi ;

Takeuchi, Tsutomu .

ARTHRITIS RESEARCH & THERAPY, 2015, 17

[45] Influence of Immunotherapy With Interferon-α on Regulatory T Cells in Renal Cell Carcinoma Patients [J].

Tatsugami, Katsunori ;

Eto, Masatoshi ;

Naito, Seiji .

JOURNAL OF INTERFERON AND CYTOKINE RESEARCH, 2010, 30 (01) :43-47

[46] Allergen immunotherapy improves defective follicular regulatory T cells in patients with allergic rhinitis [J].

Yao, Yin ;

Wang, Zhi-Chao ;

Wang, Nan ;

Zhou, Peng-Cheng ;

Chen, Cai-Ling ;

Song, Jia ;

Pan, Li ;

Liao, Bo ;

Zhang, Xin-Hao ;

Yang, Yong-Shi ;

Xu, Xiao-Yan ;

Zhu, Rong-Fei ;

Yu, Di ;

Liu, Zheng .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2019, 144 (01) :118-128

[47] Analysis of the dysregulation between regulatory B and T cells (Breg and Treg) in human immunodeficiency virus (HIV)-infected patients [J].

Gutierrez, Carolina ;

Lopez-Abente, Jacobo ;

Perez-Fernandez, Veronica ;

Prieto-Sanchez, Adrian ;

Correa-Rocha, Rafael ;

Moreno-Guillen, Santiago ;

Munoz-Fernandez, Maria-Angeles ;

Pion, Marjorie .

PLOS ONE, 2019, 14 (03)

[48] Comparative study of regulatory T cells expanded ex vivo from cord blood and adult peripheral blood [J].

Fan, Huahua ;

Yang, Jie ;

Hao, Jun ;

Ren, Yana ;

Chen, Liang ;

Li, Guiping ;

Xie, Rufeng ;

Yang, Yiming ;

Gao, Feng ;

Liu, Mingyao .

IMMUNOLOGY, 2012, 136 (02) :218-230

[49] Immunological changes in peripheral blood mononuclear cells of patients with metastatic renal cell carcinoma after low doses of subcutaneous immunotherapy with IFN-α-2b and IL-2 [J].

Moltó, L ;

Carballido, J ;

Manzano, L ;

Martinez-Martin, B ;

Esquivel, F ;

Chafer, J ;

Olivier, C ;

Alvarez-Mon, M .

JOURNAL OF IMMUNOTHERAPY, 1999, 22 (03) :260-267

[50] Immunophenotyping of Peripheral Blood Cells in Patients with Chronic Lymphocytic Leukemia Treated with Ibrutinib [J].

Stephan, Pierre ;

Bouherrou, Khaled ;

Guillermin, Yann ;

Michallet, Anne-Sophie ;

Grinberg-Bleyer, Yenkel .

CELLS, 2024, 13 (17)

← 1 2 3 4 5 →