Regulatory T and B cells in peripheral blood of subcutaneous immunotherapy-treated Japanese cedar pollinosis patients

被引：11

作者：

Matsuda, Masaya ^{[1
]}

Terada, Tetsuya ^{[2
]}

Tsujimoto, Nau ^{[1
]}

Morie, Yuki ^{[1
]}

Ishida, Tomoki ^{[1
]}

Takahashi, Hiromu ^{[1
]}

Hamaguchi, Junpei ^{[1
]}

Tabuchi, Yuki ^{[1
]}

Doi, Kana ^{[1
]}

Noro, Keiki ^{[2
]}

Kikuoka, Yusuke ^{[2
]}

Omura, Shuji ^{[2
]}

Yoshida, Takuya ^{[2
]}

Ayani, Yusuke ^{[2
]}

Suzuki, Manabu ^{[2
]}

Ichihara, Takahiro ^{[2
]}

Inaka, Yuko ^{[2
]}

Inui, Takaki ^{[2
]}

Kawata, Ryo ^{[2
]}

Nabe, Takeshi ^{[1
]}

机构：

[1] Setsunan Univ, Fac Pharmaceut Sci, Lab Immunopharmacol, Hirakata, Osaka, Japan

[2] Osaka Med Coll, Dept Otolaryngol Head & Neck Surg, Takatsuki, Osaka, Japan

来源：

IMMUNOTHERAPY | 2019年 / 11卷 / 06期

关键词：

allergies; cellular immunology; clinical immunology; immunological markers; immunotherapy; ALLERGEN-SPECIFIC IMMUNOTHERAPY; DUST MITE IMMUNOTHERAPY; TRANSCRIPTION FACTOR; IL-10; PRODUCTION; CLINICAL-EFFICACY; IMMUNE-RESPONSES; MECHANISMS; INDUCTION; TOLERANCE; ASTHMA;

D O I：

10.2217/imt-2018-0170

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Aim: The aim of this study was to clarify whether there are more regulatory T (Treg) and regulatory B (Breg) cells, and higher levels of IL-10-related transcription factors in subcutaneous immunotherapy (SCIT)-treated pollinosis patients than in non-SCIT-treated patients. Methods: Japanese cedar pollinosis patients undergoing SCIT had received treatment for at least 2.8 years. Peripheral blood mononuclear cells were used for flow cytometer analyses and mRNA measurement. Results: The numbers of type 1 regulatory T (Tr1)-like cells and Breg cells, and expression of E4BP4 mRNA by peripheral blood mononuclear cells in SCIT-treated patients were higher than those in non-SCIT-treated patients. Conclusion: Tr1-like cells, Breg cells and E4BP4 may be involved in the effectiveness of SCIT.

引用

页码：473 / 482

页数：10

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