Regulatory T and B cells in peripheral blood of subcutaneous immunotherapy-treated Japanese cedar pollinosis patients

被引：11
|
作者：
Matsuda, Masaya [1 ]
Terada, Tetsuya [2 ]
Tsujimoto, Nau [1 ]
Morie, Yuki [1 ]
Ishida, Tomoki [1 ]
Takahashi, Hiromu [1 ]
Hamaguchi, Junpei [1 ]
Tabuchi, Yuki [1 ]
Doi, Kana [1 ]
Noro, Keiki [2 ]
Kikuoka, Yusuke [2 ]
Omura, Shuji [2 ]
Yoshida, Takuya [2 ]
Ayani, Yusuke [2 ]
Suzuki, Manabu [2 ]
Ichihara, Takahiro [2 ]
Inaka, Yuko [2 ]
Inui, Takaki [2 ]
Kawata, Ryo [2 ]
Nabe, Takeshi [1 ]
机构：
[1] Setsunan Univ, Fac Pharmaceut Sci, Lab Immunopharmacol, Hirakata, Osaka, Japan
[2] Osaka Med Coll, Dept Otolaryngol Head & Neck Surg, Takatsuki, Osaka, Japan
来源：
IMMUNOTHERAPY | 2019年 / 11卷 / 06期
关键词：
allergies; cellular immunology; clinical immunology; immunological markers; immunotherapy; ALLERGEN-SPECIFIC IMMUNOTHERAPY; DUST MITE IMMUNOTHERAPY; TRANSCRIPTION FACTOR; IL-10; PRODUCTION; CLINICAL-EFFICACY; IMMUNE-RESPONSES; MECHANISMS; INDUCTION; TOLERANCE; ASTHMA;
D O I：
10.2217/imt-2018-0170
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Aim: The aim of this study was to clarify whether there are more regulatory T (Treg) and regulatory B (Breg) cells, and higher levels of IL-10-related transcription factors in subcutaneous immunotherapy (SCIT)-treated pollinosis patients than in non-SCIT-treated patients. Methods: Japanese cedar pollinosis patients undergoing SCIT had received treatment for at least 2.8 years. Peripheral blood mononuclear cells were used for flow cytometer analyses and mRNA measurement. Results: The numbers of type 1 regulatory T (Tr1)-like cells and Breg cells, and expression of E4BP4 mRNA by peripheral blood mononuclear cells in SCIT-treated patients were higher than those in non-SCIT-treated patients. Conclusion: Tr1-like cells, Breg cells and E4BP4 may be involved in the effectiveness of SCIT.
引用
收藏
页码：473 / 482
页数：10
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