Current and future antenatal management of isolated congenital diaphragmatic hernia

被引：32
作者：
Russo, Francesca Maria [1 ,2 ]
De Coppi, Paolo [1 ,2 ,3 ,4 ,5 ]
Allegaert, Karel [1 ,2 ,6 ]
Toelen, Jaan [1 ,2 ]
van der Veeken, Lennart [1 ,2 ]
Attilakos, George [3 ,4 ]
Eastwood, Mary Patrice [1 ,2 ,3 ,4 ]
David, Anna Louise [3 ,4 ]
Deprest, Jan [1 ,2 ,3 ,4 ]
机构：
[1] Katholieke Univ Leuven, Acad Dept Dev & Regenerat, Clin Specialties Res Grp, Biomed Sci, Leuven, Belgium
[2] Katholieke Univ Leuven, Clin Dept Obstet & Gynaecol, Leuven, Belgium
[3] UCL, Inst Womens Hlth, London, England
[4] UCL, Inst Child Hlth, London, England
[5] Great Ormond St Hosp Sick Children, London, England
[6] Erasmus MC, Intens Care Unit Children, Sophia Hosp Children, Rotterdam, Netherlands
来源：
SEMINARS IN FETAL & NEONATAL MEDICINE | 2017年 / 22卷 / 06期
基金：
英国惠康基金; 英国工程与自然科学研究理事会;
关键词：
Congenital diaphragmatic hernia; Prenatal therapy; Pulmonary hypoplasia; Pulmonary hypertension; Sildenafil; ENDOSCOPIC TRACHEAL OCCLUSION; PULMONARY ARTERIAL-HYPERTENSION; EXTRACORPOREAL MEMBRANE-OXYGENATION; RANDOMIZED-CONTROLLED-TRIAL; SILDENAFIL CITRATE THERAPY; AND/OR SILDENAFIL; PERFUSION MODEL; RABBIT MODEL; NITRIC-OXIDE; DOUBLE-BLIND;
D O I：
10.1016/j.siny.2017.11.002
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
Congenital diaphragmatic hernia is surgically correctable, yet the poor lung development determines mortality and morbidity. In isolated cases the outcome may be predicted prenatally by medical imaging. Cases with a poor prognosis could be treated before birth. However, prenatal modulation of lung development remains experimental. Fetoscopic endoluminal tracheal occlusion triggers lung growth and is currently being evaluated in a global clinical trial. Prenatal transplacental sildenafil administration may in due course be a therapeutic approach, reducing the occurrence of persistent pulmonary hypertension, either alone or in combination with fetal surgery. (C) 2017 Elsevier Ltd. All rights reserved.
引用
收藏
页码：383 / 390
页数：8
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