The induction of Treg cells by gut-indigenous Clostridium

被引：149

作者：

Nagano, Yuji ^{[1
]}

Itoh, Kikuji ^{[2
]}

Honda, Kenya ^{[1
]}

机构：

[1] Univ Tokyo, Dept Immunol, Grad Sch Med, Bunkyo Ku, Tokyo 1130033, Japan

[2] Univ Tokyo, Lab Vet Publ Hlth, Grad Sch Agr & Life Sci, Bunkyo Ku, Tokyo 1130033, Japan

来源：

CURRENT OPINION IN IMMUNOLOGY | 2012年 / 24卷 / 04期

基金：

日本学术振兴会; 日本科学技术振兴机构;

关键词：

REGULATORY T-CELLS; GROWTH-FACTOR-BETA; INTESTINAL MICROBIOTA; DENDRITIC CELLS; CROHNS-DISEASE; RETINOIC-ACID; BACTERIAL FLAGELLIN; INFLAMMATION; FOXP3; INTERLEUKIN-10;

D O I：

10.1016/j.coi.2012.05.007

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Foxp3(+) CD4(+) cells are prominent immune regulatory T (Treg) cells that are most abundant in the intestine. Recent studies have suggested that intestinal Treg cells consist of thymically and extrathymically developed cells that have unique characteristics. A fraction of intestinal Treg cells express T cell receptors that recognize antigens that are derived from the gut microbiota. The presence of the gut microbiota, particularly the Clostridium species, affects the development and function of Treg cells. These intestinal bacteria-induced Treg cells are likely to play a role in the tolerance toward the gut microbiota. These recent advances provide new insight into how T cells are educated in the intestine to maintain homeostasis with the gut microbiota.

引用

页码：392 / 397

页数：6

共 63 条

[61] Twin Studies Reveal Specific Imbalances in the Mucosa-associated Microbiota of Patients with Ileal Crohn's Disease [J].