Novel benzimidazolium salts and their silver complexes: Synthesis and antibacterial properties

被引:59
作者
Gunal, Selami [2 ]
Kaloglu, Nazan [1 ]
Ozdemir, Ilknur [1 ]
Demir, Serpil [1 ]
Ozdemir, Ismail [1 ]
机构
[1] Inonu Univ, Fac Sci & Arts, Dept Chem, TR-44280 Malatya, Turkey
[2] Inonu Univ, Fac Pharm, Dept Microbiol, TR-44280 Malatya, Turkey
关键词
Antibacterial; Benzimidazolium salts; N-heterocyclic carbene; Silver NHC complexes; N-HETEROCYCLIC CARBENES; CROSS-COUPLING REACTIONS; SILVER(I)-CARBENE COMPLEXES; ANTIMICROBIAL ACTIVITY; ANTICANCER PROPERTIES; PALLADIUM COMPLEXES; OLEFIN METATHESIS; SULFADIAZINE; MECHANISM; CATALYSTS;
D O I
10.1016/j.inoche.2012.04.033
中图分类号
O61 [无机化学];
学科分类号
070301 ; 081704 ;
摘要
A series of-unsymmetrical N,N-disubstituted benzimidazolium salts were synthesized as N-heterocyclic carbene (NHC) precursors. These compounds were used to synthesize of N-heterocyclic carbene silver(I) complexes. New compounds were characterized by NMR and IR spectroscopies and elemental analyses. The antibacterial activity of all the compounds was tested against Gram (+)/(-) and fungal strains using the agar dilution procedure. (C) 2012 Elsevier B.V. All rights reserved.
引用
收藏
页码:142 / 146
页数:5
相关论文
共 47 条
[1]   Synthesis and evaluation of some new benzimidazole derivatives as potential antimicrobial agents [J].
Ansari, K. F. ;
Lal, C. .
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2009, 44 (05) :2294-2299
[2]   A STABLE CRYSTALLINE CARBENE [J].
ARDUENGO, AJ ;
HARLOW, RL ;
KLINE, M .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1991, 113 (01) :361-363
[3]  
Carlsson E, 2002, CHEM BRIT, V38, P42
[4]   SILVER SULFADIAZINE - IN-VITRO ANTIBACTERIAL ACTIVITY [J].
CARR, HS ;
WLODKOWSKI, TJ ;
ROSENKRANZ, HS .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1973, 4 (05) :585-587
[5]  
Cetinkaya B, 1996, ARZNEIMITTEL-FORSCH, V46, P1154
[6]   Synthesis and characterization of oligomeric and polymeric silver-imidazol-2-ylidene iodide complexes [J].
Chen, WZ ;
Liu, FH .
JOURNAL OF ORGANOMETALLIC CHEMISTRY, 2003, 673 (1-2) :5-12
[7]   Structural variations in novel silver(I) complexes with bitopic pyrazole/N-heterocyclic carbene ligands [J].
Chiu, PL ;
Chen, CY ;
Lee, CC ;
Hsieh, MH ;
Chuang, CH ;
Lee, HM .
INORGANIC CHEMISTRY, 2006, 45 (06) :2520-2530
[8]  
Clinical and Laboratory Standards Institute, 2002, M27A2 NCCLS
[9]  
Clinical and Laboratory Standards Institute, 2003, M7A7 CLSI
[10]   Synthesis of well-defined N-heterocyclic carbene silver(I) complexes [J].
de Frémont, P ;
Scott, NM ;
Stevens, ED ;
Ramnial, T ;
Lightbody, OC ;
Macdonald, CLB ;
Clyburne, JAC ;
Abernethy, CD ;
Nolan, SP .
ORGANOMETALLICS, 2005, 24 (26) :6301-6309