Macrophage physiological function after superparamagnetic iron oxide labeling

被引：77

作者：

Hsiao, Jong-Kai ^{[1
,5
]}

Chu, Hung-Hao ^{[5
]}

Wang, Yu-Hsiu ^{[2
]}

Lai, Chih-Wei ^{[2
]}

Choii, Pi-Tai ^{[2
]}

Hsieh, Sung-Tsang ^{[3
,4
]}

Wang, Jaw-Lin ^{[1
]}

Liu, Hon-Man ^{[5
]}

机构：

[1] Natl Taiwan Univ, Inst Biomed Engn, Taipei 10764, Taiwan

[2] Natl Taiwan Univ, Dept Chem, Taipei 10764, Taiwan

[3] Natl Taiwan Univ, Dept Anat & Cell Biol, Taipei 10764, Taiwan

[4] Natl Taiwan Univ Hosp & Coll Med, Dept Neurol, Taipei 10016, Taiwan

[5] Natl Taiwan Univ Hosp & Coll Med, Dept Med Imaging, Taipei 10016, Taiwan

来源：

NMR IN BIOMEDICINE | 2008年 / 21卷 / 08期

关键词：

phagocytosis; iron oxide; tumor necrosis factor; migration; cytokine; viability; proliferation;

D O I：

10.1002/nbm.1260

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

Our goal was to analyze the changes in morphology and physiological function (phagocytosis, migratory capabilities, humoral and cellular response, and nitric oxide secretion) of murine macrophages after labeling with a clinically used superparamagnetic iron oxide (SPIO), ferucarbotran. In SPIO-treated macrophages, nanoparticles were taken up in the cytoplasm and accumulated in a membrane-bound organelle. Macrophage proliferation and viability were not modified after SPIO labeling. Phagocytic function decreased after labeling with only 10 mu g Fe/mL SPIO, whereas other functions including migration and production of tumor necrosis factor-a and nitric oxide increased at the highest SPIO concentration (100 mu g Fe/mL). Copyright (C) 2008 John Wiley & Sons. Ltd.

引用

页码：820 / 829

页数：10

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