Organocatalytic asymmetric domino reactions:: A cascade consisting of a Michael addition and an aldehyde α-alkylation

被引：194
作者：
Enders, Dieter [1 ]
Wang, Chuan [1 ]
Bats, Jan W. [2 ]
机构：
[1] Rhein Westfal TH Aachen, Inst Organ Chem, D-52074 Aachen, Germany
[2] Goethe Univ Frankfurt, Inst Organ Chem & Chem Biol, D-60439 Frankfurt, Germany
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2008年 / 47卷 / 39期
关键词：
alkylation; amino acids; domino reactions; organocatalysis; quaternary stereocenters;
D O I：
10.1002/anie.200802532
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
(Chemical Equation Presented) A direct approach to cyclic γ-nitroaldehydes with an all-carbon-substituted quaternary stereocenter is provided by a novel organocatalytic diastereo- and enantioselective cascade consisting of a Michael addition and an aldehyde α-alkylation (see scheme). The corresponding γ-amino acids are available in two steps. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.
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收藏
页码：7539 / 7542
页数：4
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