Ketamine-like Effects After Recreational Use of Methoxetamine

被引：55

作者：

Hofer, Katharina E. ^{[1
]}

Grager, Bettina ^{[2
]}

Mueller, Daniel M. ^{[3
]}

Rauber-Luethy, Christine ^{[1
]}

Kupferschmidt, Hugo ^{[1
]}

Rentsch, Katharina M. ^{[3
]}

Ceschi, Alessandro ^{[1
]}

机构：

[1] Univ Zurich, Swiss Toxicol Informat Ctr, Assoc Inst, Zurich, Switzerland

[2] Reg Hosp, Div Psychiat, Rankweil, Austria

[3] Univ Zurich Hosp, Inst Clin Chem, CH-8091 Zurich, Switzerland

来源：

ANNALS OF EMERGENCY MEDICINE | 2012年 / 60卷 / 01期

关键词：

EMERGENCY-DEPARTMENT; ABUSERS; SERIES;

D O I：

10.1016/j.annemergmed.2011.11.018

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

Methoxetamine, the N-ethyl derivative of ketamine, is a novel recreational drug that is not at present subject to restrictive regulations in most countries. To our knowledge, no case of methoxetamine abuse has been published to date in the scientific literature, and the only sources of information are illegal drug users' Web discussion forums. We report the first case of analytically confirmed intravenous methoxetamine abuse in a 19-year-old man. Observed signs and symptoms such as tachycardia, hypertension, confusion, agitation, stupor, ataxia, mydriasis, and nystagmus were consistent with ketamine-induced adverse effects and resolved with symptomatic treatment. According to this case report, user Web reports, and the chemical structure, methoxetamine produces ketamine-like effects. Complete recovery can be expected with supportive care. [Ann Emerg Med. 2012;60:97-99]

引用

页码：97 / 99

页数：3

共 15 条

[1]

Baselt R.C., 2002, Disposition of Toxic Drugs and Chemicals in Man, V6th

[2]

Cook EC, 1983, FED PROC, V42, P2566

[3] A case of ketamine dependence with discontinuation symptoms [J].

Critchlow, Denise Gail .

ADDICTION, 2006, 101 (08) :1212-1213

[4] Patterns of use and harms associated with non-medical ketamine use [J].

Dillon, P ;

Copeland, J ;

Jansen, K .

DRUG AND ALCOHOL DEPENDENCE, 2003, 69 (01) :23-28

[5] An analysis of the 'legal high' mephedrone [J].

Gibbons, Simon ;

Zloh, Mire .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2010, 20 (14) :4135-4139

[6] KETAMINE SEDATION FOR PEDIATRIC PROCEDURES .1. A PROSPECTIVE SERIES [J].

GREEN, SM ;

NAKAMURA, R ;

JOHNSON, NE .

ANNALS OF EMERGENCY MEDICINE, 1990, 19 (09) :1024-1032

[7]

Hamilton M., VICE

[8] Chemistry, Pharmacology, and Metabolism of Emerging Drugs of Abuse [J].

Maurer, Hans H. .

THERAPEUTIC DRUG MONITORING, 2010, 32 (05) :544-549

[9] Ketamine use, cognition and psychological wellbeing: a comparison of frequent, infrequent and ex-users with polydrug and non-using controls [J].

Morgan, Celia J. A. ;

Muetzelfeldt, Leslie ;

Curran, H. Valerie .

ADDICTION, 2009, 104 (01) :77-87

[10] Development of a fully automated toxicological LC-MSn screening system in urine using online extraction with turbulent flow chromatography [J].

Mueller, Daniel M. ;

Duretz, Benedicte ;

Espourteille, Francois A. ;

Rentsch, Katharina M. .

ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2011, 400 (01) :89-100

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