Association of genetic risk score and chronic kidney disease in a Japanese population

被引：10

作者：

Fujii, Ryosuke ^{[1
]}

Hishida, Asahi ^{[2
]}

Nakatochi, Masahiro ^{[3
]}

Furusyo, Norihiro ^{[6
]}

Murata, Masayuki ^{[6
]}

Tanaka, Keitaro ^{[7
]}

Shimanoe, Chisato ^{[7
]}

Suzuki, Sadao ^{[4
]}

Watanabe, Miki ^{[4
]}

Kuriyama, Nagato ^{[8
]}

Koyama, Teruhide ^{[8
]}

Takezaki, Toshiro ^{[9
]}

Shimoshikiryo, Ippei ^{[9
]}

Arisawa, Kokichi ^{[10
]}

Katsuura-Kamano, Sakurako ^{[10
]}

Takashima, Naoyuki ^{[11
]}

Turin, Tanvir C. ^{[12
]}

Kuriki, Kiyonori ^{[13
]}

Endoh, Kaori ^{[13
]}

Mikami, Haruo ^{[14
]}

Nakamura, Yohko ^{[14
]}

Oze, Isao ^{[5
]}

Ito, Hidemi ^{[5
]}

Kubo, Michiaki ^{[15
]}

Momozawa, Yukihide ^{[15
]}

Kondo, Takaaki ^{[1
]}

Naito, Mariko ^{[2
]}

Wakai, Kenji ^{[2
]}

机构：

[1] Nagoya Univ, Grad Sch Med, Dept Pathophysiol Lab Sci, Nagoya, Aichi, Japan

[2] Nagoya Univ, Grad Sch Med, Dept Prevent Med, Nagoya, Aichi, Japan

[3] Nagoya Univ Hosp, Ctr Adv Med & Clin Res, Nagoya, Aichi, Japan

[4] Nagoya City Univ, Grad Sch Med Sci, Dept Publ Hlth, Nagoya, Aichi, Japan

[5] Aichi Canc Ctr Res Inst, Div Mol & Clin Epidemiol, Nagoya, Aichi, Japan

[6] Kyushu Univ Hosp, Dept Gen Internal Med, Fukuoka, Fukuoka, Japan

[7] Saga Univ, Fac Med, Dept Prevent Med, Saga, Japan

[8] Kyoto Prefectural Univ Med, Grad Sch Med Sci, Dept Epidemiol Community Hlth & Med, Kyoto, Japan

[9] Kagoshima Univ, Grad Sch Med & Dent Sci, Dept Int Isl & Community Med, Kagoshima, Japan

[10] Univ Tokushima, Grad Sch, Inst Hlth Biosci, Dept Prevent Med, Tokushima, Japan

[11] Shiga Univ Med Sci, Dept Prevent Med, Shiga, Japan

[12] Univ Calgary, Dept Family Med, Calgary, AB, Canada

[13] Univ Shizuoka, Lab Publ Hlth, Sch Food & Nutr Sci, Shizuoka, Japan

[14] Chiba Canc Ctr Res Inst, Canc Prevent Ctr, Chiba, Japan

[15] RIKEN Ctr Integrat Med Sci, Lab Genotyping Dev, Yokohama, Kanagawa, Japan

来源：

NEPHROLOGY | 2019年 / 24卷 / 06期

关键词：

chronic kidney disease; estimated glomerular filtration rate; genetic epidemiology; genetic risk score; GENOME-WIDE ASSOCIATION; CARDIOVASCULAR-DISEASE; RENAL-FUNCTION; TRAITS; COHORT;

D O I：

10.1111/nep.13479

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Chronic kidney disease (CKD) is a public health problem worldwide including Japan. Recent genome-wide association studies have discovered CKD susceptibility variants. We developed a genetic risk score (GRS) based on CKDassociated variants and assessed a possibility that the GRS can improve the discrimination capability for the prevalence of CKD in a Japanese population. The present study consists of 11 283 participants randomly selected from 12 Japan Multi-Institutional Collaborative Cohort Study sites. Individual GRS was constructed combining 18 single-nucleotide polymorphisms identified in a Japanese population. Participants with eGFR < 60 mL/min per 1.73 m(2) was defined as case (stage 3 CKD or higher) in this study. Logistic regression analysis was used to examine the association between the GRS and CKD risk with adjustment for sex, age, hypertension and type 2 diabetes mellitus. The frequency of individuals with CKD was 8.3%, which was relatively low compared with those previously reported in a Japanese population. The odds ratio of having CKD was 1.120 (95% confidence interval: 1.042-1.203) per 10 GRS increment in the fully adjusted model (P = 0.002). The C-statistic was significantly increased in the model with the GRS, comparing with the model without the GRS (0.720 vs 0.719, P-difference = 0.008). Increment of the GRS was associated with increased risk of CKD. Additionally, the GRS significantly improved the discriminatory ability of CKD prevalence in a Japanese population; however, the improvement of discriminatory ability brought about by the GRS seemed to be small compared with that of non-genetic CKD risk factors.

引用

页码：670 / 673

页数：4

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