Serum N1-Methylnicotinamide is Associated With Coronary Artery Disease in Chinese Patients

被引：19

作者：

Liu, Ming ^{[1
,3
]}

Chu, Jihong ^{[2
]}

Gu, Yang ^{[1
]}

Shi, Haibo ^{[1
]}

Zhang, Rusheng ^{[1
]}

Wang, Lingzhun ^{[1
]}

Chen, Jiandong ^{[1
]}

Shen, Le ^{[1
]}

Yu, Peng ^{[1
]}

Chen, Xiaohu ^{[1
]}

Ju, Wenzheng ^{[2
]}

Wang, Zhenxing ^{[1
]}

机构：

[1] Nanjing Univ Chinese Med, Affiliated Hosp, Jiangsu Prov Hosp Tradit Chinese Med, Dept Cardiol, Nanjing, Jiangsu, Peoples R China

[2] Nanjing Univ Chinese Med, Affiliated Hosp, Jiangsu Prov Hosp Tradit Chinese Med, Dept Clin Pharmacol, Nanjing, Jiangsu, Peoples R China

[3] Nanjing Univ Chinese Med, Affiliated Hosp, Jiangsu Prov Hosp Tradit Chinese Med, Inst Hypertens, Nanjing, Jiangsu, Peoples R China

来源：

JOURNAL OF THE AMERICAN HEART ASSOCIATION | 2017年 / 6卷 / 02期

基金：

中国国家自然科学基金;

关键词：

coronary angiography; coronary artery disease; inflammation; N-1-methylnicotinamide; NICOTINAMIDE-N-METHYLTRANSFERASE; 1-METHYLNICOTINAMIDE MNA; MYOCARDIAL-INFARCTION; ADIPOSE-TISSUE; ATHEROSCLEROSIS; HOMOCYSTEINE; EXPRESSION; BIOMARKERS; MORTALITY; PROTEIN;

D O I：

10.1161/JAHA.116.004328

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background-We previously reported that serum N-1 -methylnicotinamide (me-Nam), an indicator of nicotinamide N-methyltransferase activity, is associated with obesity and diabetes mellitus in Chinese patients. However, whether nicotinamide N-methyltransferase plays a role in human coronary artery disease (CAD) remains to be elucidated. We aim to investigate the associations of serum me-Nam with CAD in Chinese patients. Methods and Results-Serum me-NAM was measured by liquid chromatography-mass spectrometry in patients with (n=230) or without (n=103) CAD as defined by coronary angiography. The severity of CAD was expressed by number of diseased coronary arteries. Serum me-Nam was higher (7.65 ng/mL versus 4.95 ng/mL, P < 0.001) in patients with CAD than in those without. Serum me-Nam was positively correlated with high-sensitivity C-reactive protein and negatively correlated with high-density lipoprotein before and after adjustment for potential confounding variables (P <= 0.002). In multivariable logistic regression analyses, compared with those in the lowest tertile of serum me-NAM levels, patients in the top tertile had the highest risks for CAD (odds ratio, 4.21; 95% CI, 1.97-8.97 [P < 0.001]). After adjustment for potential confounding variables, serum me-NAM was also increased from 0- to 3-vessel disease (P for trend=0.01). Conclusions-Serum me-Nam is strongly associated with presence and severity of CAD, suggesting nicotinamide N-methyltransferase as a potential target for treating atherosclerosis in humans.

引用

页数：15

共 24 条

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