Utility Decay Rates of T1-Weighted Magnetic Resonance Imaging Contrast Based on Redox-Sensitive Paramagnetic Nitroxyl Contrast Agents

被引:9
作者
Matsumoto, Ken-ichiro [1 ,2 ]
机构
[1] Natl Inst Radiol Sci, Radiat Modifier Team, Heavy Ion Radiobiol Res Grp, Res Ctr Charged Particle Therapy,Inage Ku, Chiba 2638555, Japan
[2] NCI, Radiat Biol Branch, Ctr Canc Res, NIH, Bethesda, MD 20892 USA
关键词
nitroxyl contrast agent; redox mapping; T-1-weighted contrast; magnetic resonance imaging; tissue redox status; tumor imaging; FLOW MONITORING BFM; X-BAND EPR; SPIN LABELS; SUBCELLULAR-FRACTIONS; TUMOR; REDUCTION; OXYGEN; LIVER; METABOLISM; SPECTROSCOPY;
D O I
10.1248/bpb.32.711
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The availability and applicability of the combination of paramagnetic nitroxyl contrast agent and T-1-weighted gradient echo (GE)-based dynamic magnetic resonance imaging (MRI) measurement for redox imaging are described. The time courses of T-1-weighted GE MRI signal intensities according to first-order paramagnetic loss of a nitroxyl contrast agent were simulated for several experimental conditions. The apparent decay rate calculated based on decreasing T-1-weighted MRI contrast (k(MRI))can show an approximate value of the original decay rate (k(true)) discretionarily given for simulation with suitable experimental parameters. The difference between k(MRI) and k(true) can be sufficiently small under T-1-weighted spoiled gradient echo (SPGR) scan conditions (repetition time=75 ms, echo time=3 ms, and flip angle=45 degrees), with a conventional redox-sensitive nitroxyl contrast agent, such as 4-hydroxy-2,2,6,6,-tetramethylpiperidine-N-oxyl (TEMPOL) and/or 3-carbamoyl-2,2,5,5-tetramethylpyrrolidine-N-oxyl (carbamoyl-PROXYL), and with i.v. doses of below 1.5 mu mol/g b.w. for mice. The results of this simulation suggest that the k(MRI) of nitroxyl contrast agents can be the primary index of redox status under biological conditions.
引用
收藏
页码:711 / 716
页数:6
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