Regioselective Hydroacylation of 1,3-Dienes by Cobalt Catalysis

被引：141

作者：

Chen, Qing-An ^{[1
]}

Kim, Daniel K. ^{[1
]}

Dong, Vy M. ^{[1
]}

机构：

[1] Univ Calif Irvine, Dept Chem, Irvine, CA 92697 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2014年 / 136卷 / 10期

基金：

美国国家卫生研究院;

关键词：

FORMING TRANSFER HYDROGENATION; ALDEHYDE OXIDATION LEVEL; DIRECT INTERMOLECULAR HYDROACYLATION; ASYMMETRIC ALKENE HYDROGENATION; REDUCTIVE 3+2 CYCLOADDITION; TRANSITION-METAL-COMPLEXES; N-HETEROCYCLIC CARBENES; INTRAMOLECULAR HYDROACYLATION; ENANTIOSELECTIVE SYNTHESIS; ALKYNE HYDROACYLATION;

D O I：

10.1021/ja500268w

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We describe a cobalt-catalyzed hydroacylation of 1,3-dienes with non-chelating aldehydes. Aromatic aldehydes provide 1,4-addition products as the major isomer, while aliphatic aldehydes favor 1,2-hydroacylation products. The kinetic profile supports an oxidative cyclization mechanism involving a cobaltacycle intermediate that undergoes transformation with high regio- and stereoselectivity.

引用

页码：3772 / 3775

页数：4

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