Negative inotropic mediators released from the heart after myocardial ischaemia-reperfusion

被引：52
作者：
Stangl, V
Baumann, G
Stangl, K
Felix, SB
机构：
[1] Humboldt Univ, Med Klin, Charite, D-10098 Berlin, Germany
[2] Ernst Moritz Arndt Univ Greifswald, Klin Innere Med B, Greifswald, Germany
来源：
CARDIOVASCULAR RESEARCH | 2002年 / 53卷 / 01期
关键词：
cytokines; free radicals; ischemia; macrophages; myocytes; nitric oxide; reperfusion;
D O I：
10.1016/S0008-6363(01)00420-5
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The heart responds to ischaemic stimuli with release of negative inotropic mediators such as cytokines, platelet-activating factor, oxygen free radicals, arachidonic acids, nitric oxide, adenosine, and still unidentified "cardiodepressant factors" that modulate myocardial performance via autocrine and paracrine coupling. This review summarises experimental and clinical data on the role of negative inotropic mediators that are released from cardiac cells (including cardiomyocytes, endothelial cells, and resident mast cells) after myocardial ischaemia-reperfusion. (C) 2002 Elsevier Science B.V. All rights reserved.
引用
收藏
页码：12 / 30
页数：19
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