From mice to men - mouse models in obesity research: What can we learn?

被引：17

作者：

Scroyen, Ilse ^{[1
]}

Hemmeryckx, Bianca ^{[1
]}

Lijnen, H. Roger ^{[1
]}

机构：

[1] Katholieke Univ Leuven, Ctr Mol & Vasc Biol, Dept Cardiovasc Sci, B-3000 Louvain, Belgium

来源：

THROMBOSIS AND HAEMOSTASIS | 2013年 / 110卷 / 04期

关键词：

Animal models; obesity; transgenic animals; ADIPOSE-TISSUE DEVELOPMENT; PLASMINOGEN-ACTIVATOR INHIBITOR-1; NUTRITIONALLY INDUCED OBESITY; DIET-INDUCED OBESITY; CHROMOSOME SUBSTITUTION STRAINS; DIABETIC KK-A(Y) MICE; ANIMAL-MODELS; ADIPOCYTE DIFFERENTIATION; INSULIN-RESISTANCE; FUNCTIONAL-ROLE;

D O I：

10.1160/TH12-11-0873

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Obesity has become a world-wide epidemic and is associated with diseases such as diabetes, dyslipidaemia, cardiovascular disease and certain types of cancers. Understanding the adipose tissue developmental process, involving adipogenesis, angiogenesis and extracellular matrix remodelling, is therefore crucial to reveal the pathobiology of obesity. Experimental mouse models are extensively used to gain new insights into these processes and to evaluate the role of new key players, in particular proteolytic system components, in adipose tissue development and obesity. In this paper, we will review available in vitro and in vivo murine models of obesity and discuss their value in understanding the mechanisms contributing to obesity.

引用

页码：634 / 640

页数：7

共 87 条

[1] Adipose tissue as an endocrine organ [J].

Ahima, Rexford S. .

OBESITY, 2006, 14 :242-249

[2] The M16 mouse: An outbred animal model of early onset polygenic obesity and diabesity [J].

Allan, MF ;

Eisen, EJ ;

Pomp, D .

OBESITY RESEARCH, 2004, 12 (09) :1397-1407

[3] The gut microbiota as an environmental factor that regulates fat storage [J].

Bäckhed, F ;

Ding, H ;

Wang, T ;

Hooper, LV ;

Koh, GY ;

Nagy, A ;

Semenkovich, CF ;

Gordon, JI .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (44) :15718-15723

[4] Retinoic acid activation of the ERK pathway is required for embryonic stem cell commitment into the adipocyte lineage [J].

Bost, F ;

Caron, L ;

Marchetti, I ;

Dani, C ;

Le Marchand-Brustel, Y ;

Binétruy, B .

BIOCHEMICAL JOURNAL, 2002, 361 :621-627

[5] Declining fertility in the lethal yellow mouse is related to progressive hyperleptinemia and leptin resistance [J].

Brannian, JD ;

Furman, GM ;

Diggins, M .

REPRODUCTION NUTRITION DEVELOPMENT, 2005, 45 (02) :143-150

[6] Epidemiology, trends, and morbidities of obesity and the metabolic syndrome [J].

Bray, GA ;

Bellanger, T .

ENDOCRINE, 2006, 29 (01) :109-117

[7] MOLECULAR CHARACTERIZATION OF THE MOUSE AGOUTI LOCUS [J].

BULTMAN, SJ ;

MICHAUD, EJ ;

WOYCHIK, RP .

CELL, 1992, 71 (07) :1195-1204

[8] Genetic resistance to diet-induced obesity in chromosome substitution strains of mice [J].

Burrage, Lindsay C. ;

Baskin-Hill, Annie E. ;

Sinasac, David S. ;

Singer, Jonathan B. ;

Croniger, Colleen M. ;

Kirby, Andrew ;

Kulbokas, E. J. ;

Daly, Mark J. ;

Lander, Eric S. ;

Broman, Karl W. ;

Nadeau, Joseph H. .

MAMMALIAN GENOME, 2010, 21 (3-4) :115-129

[9] Brown adipose tissue: Function and physiological significance [J].

Cannon, B ;

Nedergaard, J .

PHYSIOLOGICAL REVIEWS, 2004, 84 (01) :277-359

[10] Leptin induces vascular permeability and synergistically stimulates angiogenesis with FGF-2 and VEGF [J].

Cao, RH ;

Brakenhielm, E ;

Wahlestedt, C ;

Thyberg, J ;

Cao, YH .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (11) :6390-6395

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