Fabrication and characterization of chitosan/gelatin/nSiO2 composite scaffold for bone tissue engineering

被引：158

作者：

Kavya, K. C. ^{[1
]}

Jayakumar, R. ^{[1
]}

Nair, Shantikumar ^{[1
]}

Chennazhi, Krishna Prasad ^{[1
]}

机构：

[1] Amrita Vishwa Vidyapeetham, Amrita Inst Med Sci & Res Ctr, Amrita Ctr Nanosci & Mol Med, Cochin 682041, Kerala, India

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2013年 / 59卷

关键词：

Chitosan; Gelatin; Scaffold; Nanocomposities; Biomaterials; Bone tissue engineering; BIOMEDICAL APPLICATIONS; CHITOSAN; GLASS; DIFFERENTIATION; BIOACTIVITY; CHITIN; CELLS; BIOMINERALIZATION; MINERALIZATION; DEGRADATION;

D O I：

10.1016/j.ijbiomac.2013.04.023

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A 3D nanocomposite scaffold of chitosan, gelatin and nano-silica was fabricated by lyophilization to test the hypothesis that incorporation of nano-SiO2 could produce a better candidate for bone tissue engineering compared to pure chitosan and chitosan/gelatin scaffolds. The prepared scaffold was characterized using SEM and FTIR. Porosity, density, swelling, degradation, mechanical integrity, biomineralization and protein adsorption studies, favored it in comparison to the conventional chitosan and chitosan/gelatin scaffolds. In vitro cyto-compatablity, cell attachment-proliferation, ALP activity studies performed using MG-63 cells, advocate its remarkable performance. These cumulative results indicate the prepared nanocomposite scaffold as a prospective candidate for bone tissue engineering. (C) 2013 Elsevier B.V. All rights reserved.

引用

页码：255 / 263

页数：9

共 45 条

[1] Regulating bone formation via controlled scaffold degradation [J].