INCREASED INCIDENCE OF STERILE ENDOPHTHALMITIS AFTER INTRAVITREAL TRIAMCINOLONE ACETONIDE IN SPRING 2006

被引:27
作者
Stepien, Kimberly E. [1 ]
Eaton, Alexander M. [2 ]
Jaffe, Glenn J. [3 ]
Davis, Janet L. [1 ]
Raja, Junaid [3 ]
Feuer, William [1 ]
机构
[1] Univ Miami, Sch Med, Bascom Palmer Eye Inst, Miami, FL USA
[2] Retina Hlth Ctr, Ft Myers, FL USA
[3] Duke Univ, Med Ctr, Ctr Eye, Durham, NC 27710 USA
来源
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES | 2009年 / 29卷 / 02期
关键词
glucocorticoids; intravitreal injections; macular edema; noninfectious endophthalmitis; retinal diseases; retrospective; sterile endophthalmitis; triamcinolone acetonide; MACULAR EDEMA; NONINFECTIOUS ENDOPHTHALMITIS; INJECTION; PSEUDOHYPOPYON; PURIFICATION; SUSPENSION;
D O I
10.1097/IAE.0b013e31818eccb3
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
Purpose: To compare the incidence of sterile endophthalmitis after intravitreal triamcinolone acetonide injections during a 6 month period in 2006 to the same period in 2005 and determine the incidence after switching to intravitreal preservative-free triamcinolone acetonide. Methods: Retrospective multicenter interventional case series in which patients receiving intravitreal triamcinolone acetonide at three institutions from March 2005 to August 2005 and from March 2006 to August 2006 and intravitreal preservative-free triamcinolone acetonide from late summer 2006 through February 2007 were reviewed for the development of sterile endophthalmitis. Results: From March 2005 to August 2005, the rate of sterile endophthalmitis was 0% at all institutions. From March 2006 to August 2006, a statistically significant increase in sterile endophthalmitis was seen at all institutions with frequencies of 3.5% to 6.3% (P < 0.001). With transition to preservative-free triamcinolone acetonide, sterile endophthalmitis over the next 6 months decreased to 0% at two sites and to 2.5% (from 5.5%) at the third institution (P < 0.009). Conclusions: A statistically significant increase in the rate of sterile endophthalmitis after intravitreal triamcinolone acetonide was seen in a 6 month period in 2006 when compared with the same period in 2005. Transition to preservative-free triamcinolone acetonide produced a frequency of sterile endophthalmitis similar to 2005.
引用
收藏
页码:207 / 213
页数:7
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