Adherence trajectories in oral therapy for chronic myeloid leukemia: Overview of a research protocol

被引：3

作者：

Yeager, Katherine A. ^{[1
]}

Waldrop-Valverde, Drenna ^{[1
]}

Paul, Sudeshna ^{[1
]}

Bruner, Deborah Watkins ^{[1
,2
]}

Klisovic, Rebecca ^{[3
]}

Burns, Emily ^{[1
]}

Mason, Tamara A. ^{[1
]}

Patel, Nisha ^{[1
]}

Jennings, Bonnie Mowinski ^{[1
]}

机构：

[1] Emory Univ, Nell Hodgson Woodruff Sch Nursing, 1520 Clifton Rd Rm 228, Atlanta, GA 30322 USA

[2] Emory Sch Med, Dept Radiat Oncol, Atlanta, GA USA

[3] Emory Sch Med, Dept Hematol & Med Oncol, Atlanta, GA USA

来源：

RESEARCH IN NURSING & HEALTH | 2020年 / 43卷 / 05期

关键词：

chronic leukemia; financial hardship; mediation adherence; side effects; TYROSINE KINASE INHIBITORS; MEDICATION ADHERENCE; FINANCIAL TOXICITY; NONADHERENCE; PATTERNS; CHILDREN; IMATINIB; COSTS; CML;

D O I：

10.1002/nur.22069

中图分类号：

R47 [护理学];

学科分类号：

1011 ;

摘要：

Over a quarter of chemotherapy regimens now include oral agents. Individuals living with cancer are now responsible for administering this lifesaving therapy at home by taking every dose as prescribed. One type of oral chemotherapy, tyrosine kinase inhibitors (TKIs), is the current recommended treatment for chronic myeloid leukemia. This targeted therapy has markedly improved survival but comes with significant side effects and financial costs. In the study described in this protocol, the investigators seek to understand the dynamic nature of TKI adherence experienced by individuals diagnosed with CML. Using a mixed-method approach in this prospective observational study, funded by the National Cancer Institute, we seek to describe subjects' adherence trajectories over 1 year. We aim to characterize adherence trajectories in individuals taking TKIs using model-based cluster analysis. Next, we will determine how side effects and financial toxicity influence adherence trajectories. Then we will examine the influence of TKI adherence trajectories on disease outcomes. Additionally, we will explore the experience of patients taking TKIs by interviewing a subset of participants in different adherence trajectories. The projected sample includes 120 individuals taking TKIs who we will assess monthly for 12 months, measuring adherence with an objective measure (Medication Event Monitoring System). Identifying differential trajectories of adherence for TKIs is important for detecting subgroups at the highest risk of nonadherence and will support designing targeted interventions. Results from this study can potentially translate to other oral agents to improve care across different types of cancer.

引用

页码：443 / 452

页数：10

共 50 条

[11] Reconceptualizing Medication Adherence: Six Phases of Dynamic Adherence [J].

Gearing, Robin E. ;

Townsend, Lisa ;

MacKenzie, Michael ;

Charach, Alice .

HARVARD REVIEW OF PSYCHIATRY, 2011, 19 (04) :177-189

[12] Trajectories of Oral Medication Adherence in Youth With Inflammatory Bowel Disease [J].

Greenley, Rachel Neff ;

Karazsia, Bryan ;

Schurman, Jennifer Verrill ;

Gumidyala, Amitha Prasad ;

Nguyen, Eve U. ;

Thomason, Molly Mishler ;

Walter, Jennifer G. ;

Noe, Joshua ;

Werlin, Steven ;

Kahn, Stacy A. .

HEALTH PSYCHOLOGY, 2015, 34 (05) :514-521

[13] Research electronic data capture (REDCap)-A metadata-driven methodology and workflow process for providing translational research informatics support [J].

Harris, Paul A. ;

Taylor, Robert ;

Thielke, Robert ;

Payne, Jonathon ;

Gonzalez, Nathaniel ;

Conde, Jose G. .

JOURNAL OF BIOMEDICAL INFORMATICS, 2009, 42 (02) :377-381

[14]

Hoadley J., 2015, IT PAYS SHOP VARIA D

[15] Understanding Patients' Adherence-Related Beliefs about Medicines Prescribed for Long-Term Conditions: A Meta-Analytic Review of the Necessity-Concerns Framework [J].

Horne, Rob ;

Chapman, Sarah C. E. ;

Parham, Rhian ;

Freemantle, Nick ;

Forbes, Alastair ;

Cooper, Vanessa .

PLOS ONE, 2013, 8 (12)

[16] Three approaches to qualitative content analysis [J].

Hsieh, HF ;

Shannon, SE .

QUALITATIVE HEALTH RESEARCH, 2005, 15 (09) :1277-1288

[17] Poor adherence is the main reason for loss of CCyR and imatinib failure for chronic myeloid leukemia patients on long-term therapy [J].

Ibrahim, Amr R. ;

Eliasson, Lina ;

Apperley, Jane F. ;

Milojkovic, Dragana ;

Bua, Marco ;

Szydlo, Richard ;

Mahon, Francois-Xavier ;

Kozlowski, Kasia ;

Paliompeis, Christos ;

Foroni, Letizia ;

Khorashad, Jamshid S. ;

Bazeos, Alex ;

Molimard, Mathieu ;

Reid, Alistair ;

Rezvani, Katayoun ;

Gerrard, Gareth ;

Goldman, John ;

Marin, David .

BLOOD, 2011, 117 (14) :3733-3736

[18] Treatment Satisfaction and Adherence to Oral Chemotherapy in Patients With Cancer [J].

Jacobs, Jamie M. ;

Pensak, Nicole A. ;

Sporn, Nora J. ;

MacDonald, James J. ;

Lennes, Inga T. ;

Safren, Steven A. ;

Pirl, William F. ;

Temel, Jennifer S. ;

Greer, Joseph A. .

JOURNAL OF ONCOLOGY PRACTICE, 2017, 13 (05) :E474-E485

[19] Out-of-Pocket Costs and Oral Cancer Medication Discontinuation in the Elderly [J].

Kaisaeng, Nantana ;

Carroll, Norman V. ;

Harpe, Spencer E. .

JOURNAL OF MANAGED CARE & SPECIALTY PHARMACY, 2014, 20 (07) :669-675

[20] CLUSTERING FOR MULTIVARIATE CONTINUOUS AND DISCRETE LONGITUDINAL DATA [J].

Komarek, Arnost ;

Komarkova, Lenka .

ANNALS OF APPLIED STATISTICS, 2013, 7 (01) :177-200

← 1 2 3 4 5 →