Combinations of radiotherapy with immunotherapy in cervical cancer

被引：20

作者：

Yang, Xiaojing ^{[1
]}

Ren, Hanru ^{[2
]}

Fu, Jie ^{[1
]}

机构：

[1] Shanghai Jiao Tong Univ, Dept Radiat Oncol, Affiliated Peoples Hosp 6, 600 Yishan Rd, Shanghai 200233, Peoples R China

[2] Fudan Univ, Shanghai Pudong Hosp, Dept Orthoped, Pudong Med Ctr, Shanghai 201300, Peoples R China

来源：

JOURNAL OF CANCER | 2022年 / 13卷 / 05期

关键词：

Immunotherapy; Radiotherapy; cervical cancer; IMMUNE CHECKPOINT INHIBITORS; RADIATION; RESPONSES; BLOCKADE; THERAPY; HYPOXIA; METASTASES; EFFICACY;

D O I：

10.7150/jca.65074

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Immunotherapy serves as another effective cancer treatment apart from surgery, chemoradiotherapy, and targeted drug therapy. Radiotherapy combined with immunotherapy has significantly improved the effective cure rate for patients in several clinical trials. It subverted the traditional view that radiotherapy kills immune cells and has immunosuppressive effects, indicating a synergistic effect of radiotherapy and immunotherapy. In this article, we reviewed and summarized the molecular mechanism of the combined use of radiotherapy and immunotherapy, as well as the clinical treatment and safety of the combination of the two. We describe the rationale for the integration of radiotherapy and immunotherapy in patients with cervical cancer, present safety and efficacy data that support this combination strategy, and highlight unanswered question sand future research needs. Besides, this study can be referenced for clinicians to guide subsequent clinical medicine.

引用

页码：1480 / 1489

页数：10

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