Immunological Effects of Yeast- and Mushroom-Derived β-Glucans

被引：40

作者：

Vetvicka, Vaclav ^{[1
]}

Vashishta, Aruna ^{[1
]}

Saraswat-Ohri, Sujata ^{[1
]}

Vetvickova, Jana ^{[1
]}

机构：

[1] Univ Louisville, Dept Pathol, Louisville, KY 40202 USA

来源：

JOURNAL OF MEDICINAL FOOD | 2008年 / 11卷 / 04期

关键词：

gene; glucan; immunology; mushrooms; yeast;

D O I：

10.1089/jmf.2007.0588

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Glucans have a long history as nonspecific biological modulators. We compared the effects of three different glucans on immune reactions. Using two different administrations (intraperitoneal and oral) and two different animal models, we showed that yeast-derived Betamune(TM) (Biorigin, Sao Paulo, Brazil) caused significant stimulation of phagocytic activity as well as potentiation of synthesis and release of interleukin (IL)-1, IL-2, IL-4, IL-6, IL-8, IL-13, and tumor necrosis factor alpha. In addition, Betamune inhibited growth of tumor cells in vivo and affected expression of several important genes in breast cancer cells. Compared to adult mice, young animals showed different sensitivity to glucan action.

引用

页码：615 / 622

页数：8

共 33 条

[1] EFFECT OF LENTINAN AND MANNAN ON PHAGOCYTOSIS OF FLUORESCENT LATEX MICROBEADS BY MOUSE PERITONEAL-MACROPHAGES - A FLOW CYTOMETRIC STUDY [J].