Microwave-assisted one-pot synthesis of 2-amino-6,7-disubstituted-5-methyl-5,8-dihydropyrido[2,3-d]pyrimidin-4(3H)-one without catalyst

被引：14

作者：

Tu, SJ ^{[1
]}

Zhang, JY ^{[1
]}

Xiang, Z ^{[1
]}

Fang, F ^{[1
]}

Li, TJ ^{[1
]}

机构：

[1] Xuzhou Normal Univ, Dept Chem, Key Lab Biotechnol Med Plants, Xuzhou 221116, Jiangsu, Peoples R China

来源：

ARKIVOC | 2005年

关键词：

dihydropyridopyrimidine derivatives; microwave irradiation; environmentally friendly;

D O I：

10.3998/ark.5550190.0006.e09

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of 2-amino-6,7-disubstituted-5-methyl-5,8-dihydropyrido[2,3-d]pyrimidin-4(3H)-one derivatives were synthesized through one-pot condensation of 2,6-diaminopyrimidin-4-one, aldehyde and acyclic 1,3-dicarbonyl compounds in glycol under microwave irradiation without catalyst. The protocol in the absence of catalyst has the advantage of good yield (89-95%), short reaction time and being environmentally friendly.

引用

页码：76 / 81

页数：6

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