Transdermal nanoemulsions of Foeniculum vulgare Mill. essential oil: Preparation, characterization and evaluation of antidiabetic potential

被引:36
作者
Mostafa, Dina Mahmoud [1 ]
Abd El-Alim, Sameh Hosam [1 ]
Asfour, Marwa Hasanin [1 ]
Al-Okbi, Sahar Youssef [2 ]
Mohamed, Doha Abdou [2 ]
Awad, Gamal [3 ]
机构
[1] Natl Res Ctr, Dept Pharmaceut Technol, Giza 12311, Egypt
[2] Natl Res Ctr, Food Sci & Nutr Dept, Giza 12311, Egypt
[3] Natl Res Ctr, Chem Nat & Microbial Prod Dept, Giza 12311, Egypt
关键词
Nanoemulsions; Transdermal; Fennel; Drug delivery; IN-WATER NANOEMULSIONS; INDUCED DIABETIC-RATS; DRUG-DELIVERY; BLOOD-GLUCOSE; ANTIBACTERIAL ACTIVITY; ALDOSE REDUCTASE; SKIN PENETRATION; STRATUM-CORNEUM; TRANS-ANETHOLE; STREPTOZOTOCIN;
D O I
10.1016/j.jddst.2015.06.021
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Foeniculum vulgare Mill., family Umbelliferae, is well known for its essential oil. One of the major components of F. vulgare seed's essential oil is trans-anethole. F vulgare (fennel) possesses antioxidant and antidiabeic activities. Transdermal nanoemulsions (NEs) were employed to encapsulate fennel essential oil (EEO) with the aim of attaining effective prolonged antidiabetic action. A large NE existence area was obtained on phase diagrams employing oleic acid; oil phase and Tween20/propylene glycol; Smix in the ratios 1:1, 2:1 and 3:1 and water. Encapsulation efficiency was evaluated for trans-anethole (TA) by HPLC analysis and reached 64% in the prepared NEs. NEs were characterized for thermodynamic stability, conductivity, pH, particle size and zeta potential. Values obtained were promising. Permeation profiles for 24 h showed the superiority of EEO NE, F1, which showed also a high potential of reducing plasma glucose levels in rats which continued for 7-days after a single topical application of a dose of 120 mg/Kg of FEO. These results highlight the high efficiency of F1, formed of 2% FEO, 5.6% oleic acid, 68% Smix (1:1) and distilled water, in bringing glucose levels to normal in diabetic rats. (C) 2015 Elsevier B.V. All rights reserved.
引用
收藏
页码:99 / 106
页数:8
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