Protective effect of sesquiterpene lactone parthenolide on LPS-induced acute lung injury

被引：15

作者：

Jang, You Jin ^{[1
]}

Back, Moon Jung ^{[1
]}

Fu, Zhicheng ^{[1
]}

Lee, Joo Hyun ^{[1
]}

Won, Jong Hoon ^{[1
]}

Ha, Hae Chan ^{[1
]}

Lee, Hae Kyung ^{[1
]}

Jang, Ji Min ^{[1
]}

Choi, Jong Min ^{[1
]}

Kim, Dae Kyong ^{[1
]}

机构：

[1] Chung Ang Univ, Dept Environm & Hlth Chem, Coll Pharm, 84 Heukseok Ro, Seoul 156756, South Korea

来源：

ARCHIVES OF PHARMACAL RESEARCH | 2016年 / 39卷 / 12期

关键词：

Acute lung injury; LPS; Parthenolide; KAPPA-B ACTIVATION; RESPIRATORY-DISTRESS-SYNDROME; ALVEOLAR MACROPHAGES; LIPOPOLYSACCHARIDE; INFLAMMATION; INHIBITION; CELLS; CYTOKINES; KINASE; MICE;

D O I：

10.1007/s12272-016-0716-x

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Acute lung injury (ALI) is a respiratory failure disease and the major source of mortality in the critically ill patients. The main pathological changes involved in ALI include the excessive recruitment and activation of neutrophils by increased pro-inflammatory mediators. However, any specific therapy for ALI has not been developed. The objective of this study was to investigate protective effects of parthenolide, a sesquiterpene lactone produced in feverfew, on LPS-induced lung injury. In the present study, parthenolide treatment reduced infiltration of inflammatory cells, airway permeability and production of pro-inflammatory cytokines in LPS-induced ALI mouse model. Further, LPS-stimulated phosphorylation of NF-kappa B, the key regulatory transcription factor in ALI, was inhibited by parthenolide treatment in lung epithelial BEAS-2B cells and alveolar macrophage MH-S cells. These results suggest that parthenolide may provide a beneficial therapeutic strategy for ALI.

引用

页码：1716 / 1725

页数：10

共 35 条

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