Relationship of phenolic composition of selected purple maize (Zea mays L.) genotypes with their anti-inflammatory, anti-adipogenic and anti-diabetic potential

被引：72
作者：
Zhang, Qiaozhi [1 ,2 ]
de Mejia, Elvira Gonzalez [1 ]
Luna-Vital, Diego [1 ]
Tao, Tianyi [3 ]
Chandrasekaran, Subhiksha [1 ]
Chatham, Laura [4 ]
Juvik, John [4 ]
Singh, Vijay [5 ]
Kumar, Deepak [5 ]
机构：
[1] Univ Illinois, Dept Food Sci & Human Nutr, Urbana, IL 61801 USA
[2] Northeast Agr Univ, Coll Food Sci, Harbin 150030, Heilongjiang, Peoples R China
[3] Zhejiang Univ, Coll Agr & Biotechnol, Hangzhou, Zhejiang, Peoples R China
[4] Univ Illinois, Dept Crop Sci, Urbana, IL 61801 USA
[5] Univ Illinois, Dept Agr & Biol Engn, Urbana, IL 61801 USA
来源：
FOOD CHEMISTRY | 2019年 / 289卷
关键词：
Phenolics; Purple maize; Inflammation; Obesity; Diabetes; Principal component analysis; DIPEPTIDYL-PEPTIDASE IV; BIOACTIVE COMPOUNDS; INSULIN-RESISTANCE; HEPATIC STEATOSIS; ALPHA-GLUCOSIDASE; ADIPOSE-TISSUE; CORN; ANTHOCYANINS; ANTIOXIDANT; OBESITY;
D O I：
10.1016/j.foodchem.2019.03.116
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
This study aimed to investigate the associations between phenolic composition of selected purple maize genotypes and their anti-inflammatory, anti-adipogenic and anti-diabetic properties in vitro. Anthocyanin-rich water extracts (PMWs) from 20 purple maize genotypes were evaluated in RAW 264.7 macrophages and 3T3-L1 adipocytes under different conditions. Cyanidin-3-O-glucoside (C3G), pelargonidin-3-O-glucoside (Pr3G), peonidin-3-O-glucoside (P3G) and corresponding acylated forms were major anthocyanins in PMW, accompanied by ten tentatively identified non-anthocyanin phenolics. Correlation studies showed that C3G, P3G, and derivatives, but not Pr3G and its acylated form contributed to the biological properties of PMW. Besides anthocyanins, quercetin, luteolin, and rutin were the dominant anti-inflammatory and anti-diabetic components, in terms of down-regulating pro-inflammatory mediator production in inflamed macrophages and adipocytes, modulating diabetes-related key enzymes and improving insulin sensitivity in insulin-resistant adipocytes. Quercetin and phenolic acids, especially vanillic acid and protocatechuic acid, were closely associated with anti-adipogenic properties of PMW via inhibition of the preadipocyte-adipocyte transition.
引用
收藏
页码：739 / 750
页数：12
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