Interstitial Collagen Catabolism

被引:150
作者
Fields, Gregg B. [1 ]
机构
[1] Torrey Pines Inst Mol Studies, Port St Lucie, FL 34987 USA
基金
美国国家卫生研究院;
关键词
HUMAN CATHEPSIN-K; MATRIX-METALLOPROTEINASE ACTIVITIES; NATIVE TYPE-I; NEUTROPHIL COLLAGENASE; SUBSTRATE-SPECIFICITY; GELATINASE-A; FIBROBLAST COLLAGENASE; MOLECULAR-MECHANISM; THERMAL-STABILITY; CATALYTIC DOMAIN;
D O I
10.1074/jbc.R113.451211
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Interstitial collagen mechanical and biological properties are altered by proteases that catalyze the hydrolysis of the collagen triple-helical structure. Collagenolysis is critical in development and homeostasis but also contributes to numerous pathologies. Mammalian collagenolytic enzymes include matrix metalloproteinases, cathepsin K, and neutrophil elastase, and a variety of invertebrates and pathogens possess collagenolytic enzymes. Components of the mechanism of action for the collagenolytic enzyme MMP-1 have been defined experimentally, and insights into other collagenolytic mechanisms have been provided. Ancillary biomolecules may modulate the action of collagenolytic enzymes.
引用
收藏
页码:8785 / 8793
页数:9
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