Gene expression profiling in breast cancer: A clinical perspective

被引：60

作者：

Arpino, Grazia ^{[1
]}

Generali, Daniele ^{[9
]}

Sapino, Anna ^{[2
]}

Lucia, Del Matro ^{[3
]}

Frassoldati, Antonio ^{[4
]}

de Laurentis, Michelino ^{[1
]}

Paolo, Pronzato ^{[3
]}

Mustacchi, Giorgio ^{[5
]}

Cazzaniga, Marina ^{[6
]}

De Placido, Sabino ^{[1
]}

Conte, Pierfranco ^{[4
]}

Cappelletti, Mariarosa ^{[8
,9
]}

Zanoni, Vanessa ^{[8
,9
]}

Antonelli, Andrea ^{[8
,9
]}

Martinotti, Mario ^{[9
]}

Puglisi, Fabio ^{[8
]}

Berruti, Alfredo ^{[7
]}

Bottini, Alberto ^{[9
]}

Dogliotti, Luigi ^{[7
]}

机构：

[1] Univ Naples Federico II, Dipartimento Endocrinol & Oncol Mol & Clin, Naples, Italy

[2] Univ Turin, Dept Biomed Sci & Human Oncol, I-10124 Turin, Italy

[3] Natl Inst Canc Res, Dept Med Oncol, Genoa, Italy

[4] Modena Univ Hosp, Dept Oncol Hematol & Resp Dis, Modena, Italy

[5] Univ Trieste, Ctr Oncol, Trieste, Italy

[6] S Gerardo Hosp, Med Oncol Unit, Monza, Italy

[7] Univ Turin, Dipartimento Sci Clin & Biol, Turin, Italy

[8] Univ Hosp Udine, Dept Oncol, Udine, Italy

[9] Azienda Ist Ospitalieri Cremona, Dipartmento Chirurg, Breast Unit, Unita Operat Multidisciplanare Patol Mammaria, Cremona, Italy

来源：

BREAST | 2013年 / 22卷 / 02期

关键词：

Breast cancer; Gene arrays; Gene profiles; Prognostic factors; 70-GENE PROGNOSIS-SIGNATURE; INTERNATIONAL EXPERT CONSENSUS; 21-GENE RECURRENCE SCORE; ESTROGEN-RECEPTOR; POSTMENOPAUSAL PATIENTS; MOLECULAR SUBTYPES; ADJUVANT THERAPY; VALIDATION; RISK; PREDICTION;

D O I：

10.1016/j.breast.2013.01.016

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Gene expression profiling tests are used in an attempt to determine the right treatment for the right person with early-stage breast cancer that may have spread to nearby lymph nodes but not to distant parts of the body. These new diagnostic approaches are designed to spare people who do not need additional treatment (adjuvant therapy) the side effects of unnecessary treatment, and allow people who may benefit from adjuvant therapy to receive it. In the present review we discuss in detail the major diagnostic tests available such as MammaPrint dx, Oncotype dx, PAM50, Mammostrat, IHC4, MapQuant DX, Theros-Breast Cancer Gene Expression Ratio Assay, and their potential clinical applications. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：109 / 120

页数：12

共 74 条

[1]

Abe O, 2005, LANCET, V366, P2087, DOI 10.1016/s0140-6736(05)66544-0

[2] Robust interlaboratory reproducibility of a gene expression signature measurement consistent with the needs of a new generation of diagnostic tools [J].

Ach, Robert A. ;

Floore, Arno ;

Curry, Bo ;

Lazar, Vladimir ;

Glas, Annuska M. ;

Pover, Rob ;

Tsalenko, Anya ;

Ripoche, Hugues ;

Cardoso, Fatima ;

d'Assignies, Mahasti Saghatchian ;

Bruhn, Laurakay ;

Van't Veer, Laura J. .

BMC GENOMICS, 2007, 8 (1)

[3] Adjuvant chemotherapy and timing of tamoxifen in postmenopausal patients with endocrine-responsive, node-positive breast cancer: a phase 3, open-label, randomised controlled trial [J].

Albain, Kathy S. ;

Barlow, William E. ;

Ravdin, Peter M. ;

Farrar, William B. ;

Burton, Gary V. ;

Ketchel, Steven J. ;

Cobau, Charles D. ;

Levine, Ellis G. ;

Ingle, James N. ;

Pritchard, Kathleen I. ;

Lichter, Allen S. ;

Schneider, Daniel J. ;

Abeloff, Martin D. ;

Henderson, I. Craig ;

Muss, Hyman B. ;

Green, Stephanie J. ;

Lew, Danika ;

Livingston, Robert B. ;

Martino, Silvana ;

Osborne, C. Kent .

LANCET, 2009, 374 (9707) :2055-2063

[4]

[Anonymous], 1995, J Natl Cancer Inst, V87, P1829

[5] Gene expression profiles predict complete pathologic response to neoadjuvant paclitaxel and fluorouracil, doxorubicin, and cyclophosphamide chemotherapy in breast cancer [J].

Ayers, M ;

Symmans, WF ;

Stec, J ;

Damokosh, AI ;

Clark, E ;

Hess, K ;

Lecocke, M ;

Metivier, J ;

Booser, D ;

Ibrahim, N ;

Valero, V ;

Royce, M ;

Arun, B ;

Whitman, G ;

Ross, J ;

Sneige, N ;

Hortobagyi, GN ;

Pusztai, L .

JOURNAL OF CLINICAL ONCOLOGY, 2004, 22 (12) :2284-2293

[6]

Bender RAKM, 2009, J CLIN ONCOL S, V27, p15S

[7] Recommendations from the EGAPP Working Group: can tumor gene expression in patients with breast cancer? [J].

Berg, Alfred O. ;

Grp, E. G. A. P. P. Working ;

Armstrong, Katrina ;

Botkin, Jeffrey ;

Calonge, Ned ;

Haddow, James ;

Hayes, Maxine ;

Kaye, Celia ;

Phillips, Kathryn A. ;

Piper, Margaret ;

Richards, Carolyn Sue ;

Scott, Joan A. ;

Strickland, Ora L. ;

Teutsch, Steven .

GENETICS IN MEDICINE, 2009, 11 (01) :66-73

[8] Gene signature evaluation as a prognostic tool: challenges in the design of the MINDACT trial [J].

Bogaerts, Jan ;

Cardoso, Fatima ;

Buyse, Marc ;

Braga, Sofia ;

Loi, Sherene ;

Harrison, Jillian A. ;

Bines, Jacques ;

Mook, Stella ;

Decker, Nuria ;

Ravdin, Peter ;

Therasse, Patrick ;

Rutgers, Emiel ;

van't Veer, Laura J. ;

Piccart, Martine .

NATURE CLINICAL PRACTICE ONCOLOGY, 2006, 3 (10) :540-551

[9] Validation of 70-gene prognosis signature in node-negative breast cancer [J].

Bueno-de-Mesquita, J. M. ;

Linn, S. C. ;

Keijzer, R. ;

Wesseling, J. ;

Nuyten, D. S. A. ;

van Krimpen, C. ;

Meijers, C. ;

de Graaf, P. W. ;

Bos, M. M. E. M. ;

Hart, A. A. M. ;

Rutgers, E. J. T. ;

Peterse, J. L. ;

Halfwerk, H. ;

de Groot, R. ;

Pronk, A. ;

Floore, A. N. ;

Glas, A. M. ;

van't Veer, L. J. ;

van de Vijver, M. J. .

BREAST CANCER RESEARCH AND TREATMENT, 2009, 117 (03) :483-495

[10] Validation and clinical utility of a 70-gene prognostic signature for women with node-negative breast cancer [J].

Buyse, Marc ;

Loi, Sherene ;

van't Veer, Laura ;

Viale, Giuseppe ;

Delorenzi, Mauro ;

Glas, Annuska M. ;

d'Assignies, Mahasti Saghatchian ;

Bergh, Jonas ;

Lidereau, Rosette ;

Ellis, Paul ;

Harris, Adrian ;

Bogaerts, Jan ;

Therasse, Patrick ;

Floore, Arno ;

Amakrane, Mohamed ;

Piette, Fanny ;

Rutgers, Emiel ;

Sotiriou, Christos ;

Cardoso, Fatima ;

Piccart, Martine J. .

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2006, 98 (17) :1183-1192

← 1 2 3 4 5 6 7 8 →