Focus Issue: From Genomic Mutations to Oncogenic Pathways

被引：8

作者：

Gough, Nancy R. ^{[1
]}

机构：

[1] Amer Assoc Advancement Sci, Washington, DC 20005 USA

来源：

SCIENCE SIGNALING | 2013年 / 6卷 / 268期

关键词：

WNT/BETA-CATENIN;

D O I：

10.1126/scisignal.2004149

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This two-issue series focuses on how understanding how signaling pathways are altered in cancer cells can enable researchers to develop more effective therapies. Cancer is a pleiotropic disease. Tumor cells change over time and, even within a specific tumor, cells may have different mutations and dependencies on different signaling pathways for survival or for metastatic potential. New tools and technologies for genomic- or systems-level analysis, as well as conventional biochemistry and cell biology approaches, are revealing how signaling pathways contribute to cancer development, cancer evolution, and drug resistance.

引用

页数：2

共 9 条

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