Rivaroxaban for prevention and treatment of venous thromboembolism

被引：9
|
作者：
Chan, Noel C. [1 ,2 ]
Weitz, Jeffrey, I [1 ,2 ]
机构：
[1] McMaster Univ, Thrombosis & Atherosclerosis Res Inst, Hamilton, ON, Canada
[2] McMaster Univ, Dept Med, Hamilton, ON, Canada
来源：
FUTURE CARDIOLOGY | 2019年 / 15卷 / 02期
关键词：
nonvitamin K oral antagonist; rivaroxaban; venous thromboembolism; FACTOR-XA INHIBITOR; DIRECT ORAL ANTICOAGULANTS; DEEP-VEIN THROMBOSIS; TOTAL HIP; ORTHOPEDIC-SURGERY; EXTENDED TREATMENT; KNEE REPLACEMENT; REAL-WORLD; ENOXAPARIN; THROMBOPROPHYLAXIS;
D O I：
10.2217/fca-2018-0076
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Until recently, heparins and vitamin K antagonists (VKAs) were the cornerstones for prevention and treatment of venous thromboembolism (VTE). This situation changed with the introduction of the direct oral anticoagulants, which are now replacing low-molecular-weight heparin for thromboprophylaxis after elective hip or knee arthroplasty and VKAs for VTE treatment. Rivaroxaban, an oral factor Xa inhibitor, was the first direct oral anticoagulant licensed for VTE prevention and treatment. This paper provides the rationale for factor Xa as a target for anticoagulants, describes the development of rivaroxaban, reviews its pharmacological profile, discusses the clinical trials with rivaroxaban for VTE prevention and treatment and highlights areas of uncertainty.
引用
收藏
页码：63 / 77
页数：15
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