A NEW MONOMER Ce(III) COMPLEX BASED ON BIS[(2-PYRIDYL)METHYLENE]PYRIDINE-2,6-DICARBOHYDRAZONE: SYNTHESIS, DNA BINDING, APOPTOSIS, AND MOLECULAR DOCKING

被引：0

作者：

Chen, S. Y. ^{[1
,2
]}

Ji, X. X. ^{[1
,2
]}

Song, D. X. ^{[1
,2
]}

Chen, Q. ^{[1
,2
]}

Li, Y. ^{[1
,2
]}

Sun, N. ^{[1
,2
]}

Wang, L. ^{[1
,2
]}

Wu, S. Y. ^{[1
,2
]}

Zhang, Y. ^{[1
,2
]}

Zhu, M. C. ^{[1
,2
]}

机构：

[1] Shenyang Univ Chem Technol, Key Lab Inorgan Mol Based Chem Liaoning Prov, Shenyang, Liaoning, Peoples R China

[2] Shenyang Univ Chem Technol, Lab Coordinat Chem, Shenyang, Liaoning, Peoples R China

来源：

JOURNAL OF STRUCTURAL CHEMISTRY | 2022年 / 63卷 / 10期

关键词：

monomer complex; DNA; molecular docking; apoptosis; CRYSTAL-STRUCTURE; LANTHANIDE COMPLEXES; PLATINUM DRUGS; II COMPLEXES; ACID; CYTOTOXICITY; DERIVATIVES; COMPOSITE; CLEAVAGE; THERAPY;

D O I：

10.1134/S0022476622100031

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A new type of monomer complex [Ce-3(L)(2)(NO3)(5)(DMF)(2)] was successfully synthesized by hydrothermal method. The structure of the complex was analyzed by single crystal X-ray diffraction, elemental analysis, and infrared spectroscopy. And the powder X-ray diffraction analysis was used to verify the purity of the complex. UV-Vis (Ultraviolet-visible) absorption spectroscopy shows that the complex is inserted into FS-DNA (fish sperm DNA) through the interaction with DNA base pairs via hydrogen bonds, and the binding constant K-b of DNA is 9.8.10(4) M-1. Fluorescence spectroscopy experiments revealed the binding capacity of DNA, and the fluorescence quenching constant K-sv value was 0.072.10(5 )M(-1). Molecular docking studies have shown that the complex can be effectively inserted into the small groove of DNA. Flow cytometry analyzed the ability of the complex to induce apoptosis HeLa cells (human cervical cancer cells). This series of experiences demonstrated the potential therapeutic value of this complex.

引用

页码：1568 / 1578

页数：11

共 54 条

[11] The influence of structure on the activity and toxicity of Pt anti-cancer drugs [J].