Facile, Selective, and Regiocontrolled Synthesis of Oxazolines and Oxazoles Mediated by ZnI2 and FeCl3

被引：108

作者：

Senadi, Gopal Chandru ^{[1
]}

Hu, Wan-Ping ^{[2
]}

Hsiao, Jia-Shing ^{[1
]}

Vandavasi, Jaya Kishore ^{[1
]}

Chen, Chung-Yu ^{[3
]}

Wang, Jeh-Jeng ^{[1
]}

机构：

[1] Kaohsiung Med Univ, Dept Med & Appl Chem, Kaohsiung, Taiwan

[2] Kaohsiung Med Univ, Dept Biotechnol, Kaohsiung, Taiwan

[3] Kaohsiung Med Univ, Dept Pharm, Kaohsiung, Taiwan

来源：

ORGANIC LETTERS | 2012年 / 14卷 / 17期

关键词：

GOLD CATALYSIS; STRAIGHTFORWARD SYNTHESIS; CYCLIZATION; COMPLEXES; PROPARGYLAMIDES; EFFICIENT;

D O I：

10.1021/ol301980g

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An expedient method for a direct approach to the selective and regiocontrolled synthesis of 2-oxazolines and 2-oxazoles mediated by ZnI2 and FeCl3 is described. A Lewis acid promoted cyclization of acetylenic amide with various functionalities was well tolerated to give 2-oxazolines and 2-oxazoles in good to excellent yields under mild reaction conditions.

引用

页码：4478 / 4481

页数：4

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