Animal Models and Their Contribution to Our Understanding of the Relationship Between Environments, Epigenetic Modifications, and Behavior

被引：43

作者：

Phillips, Natalia Ledo Husby ^{[1
]}

Roth, Tania L. ^{[1
]}

机构：

[1] Univ Delaware, Dept Psychol & Brain Sci, 108 Wolf Hall, Newark, DE 19716 USA

来源：

GENES | 2019年 / 10卷 / 01期

关键词：

animal models; environments; epigenetics; behavior; disease; EARLY-LIFE STRESS; ENDOCRINE DISRUPTOR VINCLOZOLIN; FETAL-BRAIN DEVELOPMENT; DNA METHYLATION; BISPHENOL AF; MATERNAL SEPARATION; IMMUNE ACTIVATION; TRANSGENERATIONAL INHERITANCE; GLUCOCORTICOID-RECEPTOR; LASTING CONSEQUENCES;

D O I：

10.3390/genes10010047

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The use of non-human animals in research is a longstanding practice to help us understand and improve human biology and health. Animal models allow researchers, for example, to carefully manipulate environmental factors in order to understand how they contribute to development, behavior, and health. In the field of behavioral epigenetics such approaches have contributed novel findings of how the environment physically interacts with our genes, leading to changes in behavior and health. This review highlights some of this research, focused on prenatal immune challenges, environmental toxicants, diet, and early-life stress. In conjunction, we also discuss why animal models were integral to these discoveries and the translational relevance of these discoveries.

引用

页数：15

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