Natural Killers out of Thin Air

被引：0
作者：
Nakamura, Kyohei [1 ]
Smyth, Mark J. [1 ]
机构：
[1] QIMR Berghofer Med Res Inst, Herston, Qld 4006, Australia
来源：
IMMUNITY | 2020年 / 52卷 / 06期
关键词：
NK CELLS;
D O I：
10.1016/j.immuni.2020.05.007
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The regulatory mechanisms controlling natural killer (NK) cells in the tumor microenvironment remain unknown. In this issue, Ni. et al. provide evidence that the transcription factor HIF-1 alpha acts as a key negative regulator of NK cell metabolic fitness in the tumor microenvironment that critically impedes NK cell anti-tumor immune responses.
引用
收藏
页码：895 / 897
页数：3
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