Noise exposure-induced enhancement of auditory cortex response and changes in gene expression

被引:53
作者
Sun, W. [1 ,2 ]
Zhang, L. [1 ]
Lu, J. [1 ]
Yang, G. [1 ]
Laundrie, E. [1 ]
Salvi, R. [1 ,2 ]
机构
[1] SUNY Buffalo, Ctr Hearing & Deafness, Buffalo, NY 14214 USA
[2] SUNY Buffalo, Dept Communicat Disorders & Sci, Buffalo, NY 14214 USA
基金
美国国家卫生研究院;
关键词
auditory cortex; gene expression; heat shock protein; noise exposure; gene microarray; tinnitus;
D O I
10.1016/j.neuroscience.2008.07.040
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Noise exposure is one of the most common causes of hearing loss. There is growing evidence suggesting that noise-induced peripheral hearing loss can also induce functional changes in the central auditory system. However, the physiological and biological changes in the central auditory system induced by noise exposure are poorly understood. To address these issues, neurophysiological recordings were made from the auditory cortex (AC) of awake rats using chronically implanted electrodes before and after acoustic overstimulation. In addition, focused gene microarrays and quantitative real-time polymerase chain reaction were used to identify changes in gene expression in the AC. Monaural noise exposure (120 dB sound pressure level, 1 h) significantly elevated hearing threshold on the exposed ear and induced a transient enhancement on the AC response amplitude 4 h after the noise exposure recorded from the unexposed ear. This increase of the cortical neural response amplitude was associated with an upregulation of genes encoding heat shock protein (HSP) 27 kDa and 70 kDa after several hours of the noise exposure. These results suggest that noise exposure can induce a fast physiological change in the AC which may be related to the changes of HSP expressions. Published by Elsevier Ltd on behalf of IBRO.
引用
收藏
页码:374 / 380
页数:7
相关论文
共 41 条
[1]   Apoptosis in auditory brainstem neurons after a severe noise trauma of the organ of Corti: Intracochlear GDNF treatment reduces the number of apoptotic cells [J].
Aarnisalo, AA ;
Pirvola, U ;
Liang, XQ ;
Miller, J ;
Ylikoski, J .
ORL-JOURNAL FOR OTO-RHINO-LARYNGOLOGY AND ITS RELATED SPECIALTIES, 2000, 62 (06) :330-334
[2]   Stress pathways in the rat cochlea and potential for protection from acquired deafness [J].
Altschuler, RA ;
Fairfield, D ;
Cho, Y ;
Leonova, E ;
Benjamin, IJ ;
Miller, JM ;
Lomax, MI .
AUDIOLOGY AND NEURO-OTOLOGY, 2002, 7 (03) :152-156
[3]   ACUTE ACOUSTIC TRAUMA [J].
AXELSSON, A ;
HAMERNIK, RP .
ACTA OTO-LARYNGOLOGICA, 1987, 104 (3-4) :225-233
[4]   Noise-induced cell death in the mouse medial geniculate body and primary auditory cortex [J].
Basta, D ;
Tzschentke, B ;
Ernst, A .
NEUROSCIENCE LETTERS, 2005, 381 (1-2) :199-204
[5]   Vigabatrin, a GABA transaminase inhibitor, reversibly eliminates tinnitus in an animal model [J].
Brozoski, Thomas J. ;
Spires, T. Joseph D. ;
Bauer, Carol A. .
JARO-JOURNAL OF THE ASSOCIATION FOR RESEARCH IN OTOLARYNGOLOGY, 2007, 8 (01) :105-118
[6]   c-fos mRNA Induction in Acute and Chronic Audiogenic Stress: Possible Role of the Orbitofrontal Cortex in Habituation [J].
Campeau, Serge ;
Dolan, David ;
Akil, Huda ;
Watson, Stanley J., Jr. .
STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS, 2002, 5 (02) :121-130
[7]   Cathepsin D-Bax death pathway in oxidative stressed neuroblastoma cells [J].
Castino, Roberta ;
Bellio, Natascia ;
Nicotra, Giuseppina ;
Follo, Carlo ;
Trincheri, Nicol F. ;
Isidoro, Ciro .
FREE RADICAL BIOLOGY AND MEDICINE, 2007, 42 (09) :1305-1316
[8]   Stress-induced heat shock protein 27 expression and its role in dorsal root ganglion neuronal survival [J].
Dodge, ME ;
Wang, JG ;
Guy, C ;
Rankin, S ;
Rahimtula, M ;
Mearow, KM .
BRAIN RESEARCH, 2006, 1068 (01) :34-48
[9]   ei24, a p53 response gene involved in growth suppressio and apoptosis [J].
Gu, ZM ;
Flemington, C ;
Chittenden, T ;
Zambetti, GP .
MOLECULAR AND CELLULAR BIOLOGY, 2000, 20 (01) :233-241
[10]   HsP70 in the inferior colliculus of Fischer-344 rats: effects of age and acoustic stress [J].
Helfert, RH ;
Glatz, FR ;
Wilson, TS ;
Ramkumar, V ;
Hughes, LF .
HEARING RESEARCH, 2002, 170 (1-2) :155-165