Enantioselective Horner-Wadsworth-Emmons reaction using chiral lithium 2-aminoalkoxides

被引：0

作者：

Kumamoto, T ^{[1
]}

Koga, K ^{[1
]}

机构：

[1] UNIV TOKYO, FAC PHARMACEUT SCI, BUNKYO KU, TOKYO 113, JAPAN

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 1997年 / 45卷 / 04期

关键词：

chiral base; chiral lithium 2-aminoalkoxide; Horner-Wadsworth-Emmons reaction; enantioselective asymmetric synthesis; chiral axis;

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Chiral lithium 2-aminoalkoxides ((1R,2S)-4) were applied as chiral bases for the enantioselective Horner-Wadsworth-Emmons reaction between achiral phosphonates (2) and 4-tert-butylcyclohexanone (1). A chiral olefin ((R)-3b) was obtained in up to 52% enantiomeric excess (ee). It is shown that the formation of the lithium aldolate intermediate is reversible and is not responsible for the asymmetric induction.

引用

页码：753 / 755

页数：3

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