Evidence of cell fusion in carcinogen-induced mice gastric carcinoma

被引：5

作者：

Yan, Yongjia ^{[1
]}

Hsu, Yiling ^{[1
]}

He, Xianghui ^{[1
]}

Lu, Ning ^{[1
]}

Wei, Wei ^{[2
]}

Zhang, Zhixiang ^{[1
]}

Zhu, Liwei ^{[1
]}

机构：

[1] Tianjin Med Univ Gen Hosp, Tianjin Gen Surg Inst, Dept Gen Surg, Tianjin 300052, Peoples R China

[2] Peoples Hosp Wuqing Dist, Dept Thorac Surg, Tianjin 301700, Peoples R China

来源：

TUMOR BIOLOGY | 2015年 / 36卷 / 07期

基金：

中国国家自然科学基金;

关键词：

Bone marrow-derived cells; Cell fusion; Carcinogenesis; Gastric carcinoma; Chimeric mice; MARROW-DERIVED CELLS; BONE-MARROW; STEM-CELLS; TRANSPLANTATION; HEPATOCYTES; RECIPIENT;

D O I：

10.1007/s13277-015-3160-5

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The role of bone marrow-derived cells in gastric cancer formation was not fully understood. In this study, bone marrow from female green fluorescent protein transgenic mice was transplanted into male wildtype mice to generate sex-mismatched chimeric mice. The chimeric mice were treated with carcinogen to induce gastric cancer. At time of sacrifice, 18.2 % (2/11) of mice showed severe dysplasia and 25 % (3/12) of mice successfully induced with cancer. Fluorescence in situ hybridization results showed that bone marrow-derived cells participated in renewal of gastric mucosa and cell fusion was observed in both precancerous lesions and adenocarcinoma, but no sign of fusion was observed in squamous cell carcinoma. Our findings suggest that bone marrow-derived cells participate in renewal of gastric mucosa during chronic damage and might have acquired the phenotype of gastric epithelial cells through cell fusion. Fusion between gastric epithelial cells and bone marrow-derived cells was involved in increased carcinogenesis.

引用

页码：5089 / 5094

页数：6

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