Synthesis, conformational analysis and antitumor testing of 5-(Z)-arylidene-4-imidazolidinone derivatives

被引：33

作者：

Khodair, AI

El-Subbagh, HI

Al-Obaid, AM

机构：

[1] Tanta Univ, Fac Educ, Dept Chem, Kafr El Sheikh Branch, Tanta, Egypt

[2] King Saud Univ, Coll Pharm, Dept Pharmaceut Chem, Riyadh 11451, Saudi Arabia

来源：

PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS | 1998年 / 140卷

关键词：

2-thioxo-4-imidazolidinone; 5-(Z)-arylidene-4-imidazolidinone derivatives; conformational analysis and antitumoral activity;

D O I：

10.1080/10426509808035741

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A series of 5-(Z)-arylidene-2-amino-4-imidazolidinones 16-34, 5-(Z)-arylidene-2-(2-carboxyphenylamino)-4-imidazolidinones 35-41, 5-(Z)-arylidene-3-aminomethyl-2-thioxo-4-imidazolidinones 42-55 and 5-(Z)-arylidene-3-aminomethyl-2-methylmercapto-4-imidazolidinones 56-67 have been synthesized via two different routes. Conformational analysis and antitumor activities have been studied. The antitumor activity of these compounds showed broad spectrum of activity against a wide range of different human cell lines of nine tumor subpanels causing both cytostatic and cytotoxic potency.

引用

页码：159 / 181

页数：23