Organocatalytic Asymmetric Michael Addition of Ketones toα,β-Unsaturated Nitro Compounds

被引：11

作者：

Shim, Jae Ho ^{[1
]}

Nam, Si Hun ^{[1
]}

Kim, Byeong-Seon ^{[2
,3
]}

Ha, Deok-Chan ^{[1
]}

机构：

[1] Korea Univ, Res Inst Nat Sci, Dept Chem, 145 Anam Ro, Seoul 02841, South Korea

[2] Gyeongsang Natl Univ, Dept Chem Educ, Jinju 52828, South Korea

[3] Gyeongsang Natl Univ, Res Inst Nat Sci, Jinju 52828, South Korea

来源：

CATALYSTS | 2020年 / 10卷 / 06期

基金：

新加坡国家研究基金会;

关键词：

organocatalyst; enantioselectivity; yield; thiourea catalyst; asymmetric; CONJUGATE ADDITION; AROMATIC KETONES; CATALYSTS; ENANTIOMERS; AMINES; DONORS;

D O I：

10.3390/catal10060618

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

An organic catalyst "(R,R)-1,2-diphenylethylenediamine(DPEN) derivative'' was devel-oped as a chiral bifunctional organocatalyst and applied for asymmetric Michael additions of aromatic ketones totrans-beta-nitroalkene compounds under neutral conditions. The isopropyl-subs-tituted thiourea catalyst in neutral condition provides high chemical yield and enantioselectivities (ee) (up to 96% yield, 98% ee).

引用

页数：11

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