Notch Signaling and the Breast Cancer Microenvironment

被引：40

作者：

Shen, Qiang ^{[1
]}

Reedijk, Michael ^{[1
]}

机构：

[1] Univ Hlth Network, Princess Margaret Canc Ctr, Dept Surg Oncol, Toronto, ON, Canada

来源：

NOTCH SIGNALING IN EMBRYOLOGY AND CANCER: NOTCH SIGNALING IN CANCER | 2020年 / 1287卷

关键词：

Notch; JAG; DLL; gamma-secretase; RBPJ kappa; Breast cancer; Triple negative; Basal-like; Tumor microenvironment; Angiogenesis; Urokinase-type plasminogen activator; Extracellular matrix; TRB3; USP9x; Cellular stress; TGF-beta; IL1; beta; CCL2; Tumor-associated macrophage; CD8+T-cell; Immunophenotype; Cancer-associated fibroblast; PD-1; Immune checkpoint blockade; ENDOTHELIAL GROWTH-FACTOR; EPITHELIAL-MESENCHYMAL TRANSITION; IN-VITRO PROPAGATION; MAMMARY-TUMOR VIRUS; REGULATORY T-CELLS; STROMAL FIBROBLASTS; UBIQUITIN LIGASE; GENE-EXPRESSION; STEM-CELLS; MATRIX METALLOPROTEINASES;

D O I：

10.1007/978-3-030-55031-8_12

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Notch promotes breast cancer progression through tumor initiating cell maintenance, tumor cell fate specification, proliferation, survival, and motility. In addition, Notch is recognized as a decisive mechanism in regulating various juxtacrine and paracrine communications in the tumor microenvironment (TME). In this chapter, we review recent studies on stress-mediated Notch activation within the TME and sequelae such as angiogenesis, extracellular matrix remodeling, changes in the innate and adaptive immunophenotype, and therapeutic perspectives.

引用

页码：183 / 200

页数：18

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