Notch Signaling and the Breast Cancer Microenvironment

被引：33

作者：

Shen, Qiang ^{[1
]}

Reedijk, Michael ^{[1
]}

机构：

[1] Univ Hlth Network, Princess Margaret Canc Ctr, Dept Surg Oncol, Toronto, ON, Canada

来源：

NOTCH SIGNALING IN EMBRYOLOGY AND CANCER: NOTCH SIGNALING IN CANCER | 2020年 / 1287卷

关键词：

Notch; JAG; DLL; gamma-secretase; RBPJ kappa; Breast cancer; Triple negative; Basal-like; Tumor microenvironment; Angiogenesis; Urokinase-type plasminogen activator; Extracellular matrix; TRB3; USP9x; Cellular stress; TGF-beta; IL1; beta; CCL2; Tumor-associated macrophage; CD8+T-cell; Immunophenotype; Cancer-associated fibroblast; PD-1; Immune checkpoint blockade; ENDOTHELIAL GROWTH-FACTOR; EPITHELIAL-MESENCHYMAL TRANSITION; IN-VITRO PROPAGATION; MAMMARY-TUMOR VIRUS; REGULATORY T-CELLS; STROMAL FIBROBLASTS; UBIQUITIN LIGASE; GENE-EXPRESSION; STEM-CELLS; MATRIX METALLOPROTEINASES;

D O I：

10.1007/978-3-030-55031-8_12

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Notch promotes breast cancer progression through tumor initiating cell maintenance, tumor cell fate specification, proliferation, survival, and motility. In addition, Notch is recognized as a decisive mechanism in regulating various juxtacrine and paracrine communications in the tumor microenvironment (TME). In this chapter, we review recent studies on stress-mediated Notch activation within the TME and sequelae such as angiogenesis, extracellular matrix remodeling, changes in the innate and adaptive immunophenotype, and therapeutic perspectives.

引用

页码：183 / 200

页数：18

共 50 条

[1] Role of Notch and its oncogenic signaling crosstalk in breast cancer
Guo, Shanchun
Liu, Mingli
Gonzalez-Perez, Ruben R.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER, 2011, 1815 (02): : 197 - 213
[2] Tumor microenvironment and breast cancer progression A complex scenario
Artacho-Cordon, Antonia
Artacho-Cordon, Francisco
Rios-Arrabal, Sandra
Calvente, Irene
Isabel Nunez, Maria
CANCER BIOLOGY & THERAPY, 2012, 13 (01) : 14 - 24
[3] Notch Signaling in Breast Tumor Microenvironment as Mediator of Drug Resistance
Chimento, Adele
D'Amico, Maria
Pezzi, Vincenzo
De Amicis, Francesca
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2022, 23 (11)
[4] Recruitment of stromal cells into tumour microenvironment promote the metastatic spread of breast cancer
Hill, Billy Samuel
Sarnella, Annachiara
D'Avino, Giuliana
Zannetti, Antonella
SEMINARS IN CANCER BIOLOGY, 2020, 60 : 202 - 213
[5] NOTCH SIGNALING AND BREAST CANCER
Reedijk, Michael
NOTCH SIGNALING IN EMBRYOLOGY AND CANCER, 2012, 727 : 241 - 257
[6] CCL25 Signaling in the Tumor Microenvironment
Mir, Hina
Singh, Shailesh
TUMOR MICROENVIRONMENT: THE ROLE OF CHEMOKINES - PT B, 2021, 1302 : 99 - 111
[7] Cancer-associated fibroblasts as key regulators of the breast cancer tumor microenvironment
Houthuijzen, J. M.
Jonkers, J.
CANCER AND METASTASIS REVIEWS, 2018, 37 (04) : 577 - 597
[8] Notch Signaling Pathway and Endocrine Resistance in Breast Cancer
Bai, Jing-Wen
Wei, Min
Li, Ji-Wei
Zhang, Guo-Jun
FRONTIERS IN PHARMACOLOGY, 2020, 11
[9] Notch Signaling in Breast Cancer: A Role in Drug Resistance
BeLow, McKenna
Osipo, Clodia
CELLS, 2020, 9 (10)
[10] Notch signaling, hypoxia, and cancer
Guo, Mingzhou
Niu, Yang
Xie, Min
Liu, Xiansheng
Li, Xiaochen
FRONTIERS IN ONCOLOGY, 2023, 13

← 1 2 3 4 5 →