Anti-streptococcal, tubulin, and dopamine receptor 2 antibodies in children with PANDAS and Tourette syndrome: Single-point and longitudinal assessments

被引：37

作者：

Morris-Berry, C. M. ^{[1
]}

Pollard, M. ^{[1
]}

Gao, S. ^{[1
]}

Thompson, C. ^{[2
]}

Singer, H. S. ^{[1
,3
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21287 USA

[2] Johns Hopkins Sch Publ Hlth, Dept Stat Serv, Baltimore, MD 21205 USA

[3] Johns Hopkins Univ, Sch Med, Dept Pediat, Baltimore, MD 21287 USA

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2013年 / 264卷 / 1-2期

关键词：

PANDAS; Tourette syndrome; Anti-neuronal antibodies; D2; receptor; Tubulin; Single-point and longitudinal; OBSESSIVE-COMPULSIVE SYMPTOMS; STREPTOCOCCAL INFECTION; DIFFERENTIATE PANDAS; SERUM AUTOANTIBODIES; NEURONAL SURFACE; SYDENHAM CHOREA; TIC DISORDERS; EXACERBATIONS; MOVEMENT; BEHAVIOR;

D O I：

10.1016/j.jneuroim.2013.09.010

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Single-point-in-time ELISA optical densities for three putative antibodies identified in Sydenham's chorea, the streptococcal group A carbohydrate antigen, N-acetyl-beta-o-glucosamine, tubulin, and the dopamine 2 receptor, showed no differences in children with PANDAS (n = 44) or Tourette syndrome (n = 40) as compared to controls (n = 24). Anti-tubulin and D2 receptor antibodies assessed in serial samples from 12 PANDAS subjects obtained prior to a documented exacerbation, during the exacerbation (with or without a temporally associated streptococcal infection), and following the exacerbation, showed no evidence of antibody levels correlating with a clinical exacerbation. These data do not support hypotheses suggesting an autoimmune hypothesis in either TS or PANDAS. (C) 2013 Elsevier B.V. All rights reserved.

引用

页码：106 / 113

页数：8