What Can We Learn and What Do We Need to Know Amidst the Iatrogenic Outbreak of Exserohilum Rostratum Meningitis?

被引：18

作者：

Kontoyiannis, Dimitrios P. ^{[1
,2
]}

Perlin, David S. ^{[2
,3
]}

Roilides, Emmanuel ^{[2
,4
,5
]}

Walsh, Thomas J. ^{[2
,5
,6
,7
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Dept Infect Dis, Houston, TX 77030 USA

[2] Univ Med & Dent New Jersey, Exserohilum Meningitis Res Consortium, Newark, NJ USA

[3] Univ Med & Dent New Jersey, Int Ctr Publ Hlth, Publ Hlth Res Inst, Newark, NJ USA

[4] Aristotle Univ Thessaloniki, Hippokrat Gen Hosp, Dept Pediat 3, GR-54006 Thessaloniki, Greece

[5] Weill Cornell Med Ctr, Transplantat Oncol Infect Dis Program, Div Infect Dis, New York, NY USA

[6] Weill Cornell Med Ctr, Dept Pediat, New York, NY USA

[7] Weill Cornell Med Ctr, Dept Microbiol & Immunol, New York, NY USA

来源：

CLINICAL INFECTIOUS DISEASES | 2013年 / 57卷 / 06期

关键词：

Exserohilum rostratum; meningoencephalitis; antifungals; risk factors; pathogenesis; AMPHOTERICIN-B; PARACOCCIDIOIDES-BRASILIENSIS; CEREBROSPINAL-FLUID; XYLOHYPHA-BANTIANA; FUNGAL-INFECTIONS; THERAPY; PHARMACOKINETICS; PHEOHYPHOMYCOSIS; ASPERGILLUS; RESISTANCE;

D O I：

10.1093/cid/cit283

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The tragedy of the ongoing epidemic of meningitis caused by Exserohilum rostratum brings into focus the epidemiology, risk factors, pathogenesis, diagnosis, and treatment of a multitude of opportunistic mold infections of the central nervous system. Herein we provide our perspective regarding the translational research objectives of this infection that are needed to make an impact on this important healthcare crisis.

引用

页码：853 / 859

页数：7

共 44 条

[1]

Aristizábal BH, 2002, MED MYCOL, V40, P169, DOI 10.1080/mmy.40.2.169.178

[2] Phaeohyphomycosis in a Tertiary Care Cancer Center [J].

Ben-Ami, Ronen ;

Lewis, Russell E. ;

Raad, Issam I. ;

Kontoyiannis, Dimitrios P. .

CLINICAL INFECTIOUS DISEASES, 2009, 48 (08) :1033-1041

[3]

Centers for Disease Control and Prevention (CDC), 2012, MMWR Morb Mortal Wkly Rep, V61, P842

[4] Experimental Central Nervous System Aspergillosis Therapy: Efficacy, Drug Levels and Localization, Immunohistopathology, and Toxicity. [J].

Clemons, Karl V. ;

Schwartz, Julie A. ;

Stevens, David A. .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2012, 56 (08) :4439-4449

[5] Molecular Identification and In Vitro Response to Antifungal Drugs of Clinical Isolates of Exserohilum [J].

da Cunha, Keith Cassia ;

Sutton, Deanna A. ;

Gene, Josepa ;

Capilla, Javier ;

Cano, Josep ;

Guarro, Josep .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2012, 56 (09) :4951-4954

[6]

DIXON DM, 1989, REV INFECT DIS, V11, P515

[7]

DIXON DM, 1991, MYCOSES, V34, P1, DOI 10.1111/j.1439-0507.1991.tb00613.x

[8] COCCIDIOIDOMYCOSIS - FACTORS AFFECTING THE HOST-PARASITE INTERACTION [J].

DRUTZ, DJ ;

HUPPERT, M .

JOURNAL OF INFECTIOUS DISEASES, 1983, 147 (03) :372-390

[9] Molecular cloning and characterization of WdPKS1, a gene involved in dihydroxynaphthalene melanin biosynthesis and virulence in Wangiella (Exophiala) dermatitidis [J].

Feng, B ;

Wang, X ;

Hauser, M ;

Kaufmann, S ;

Jentsch, S ;

Haase, G ;

Becker, JM ;

Szaniszlo, PJ .

INFECTION AND IMMUNITY, 2001, 69 (03) :1781-1794

[10]

Flores VG, 2012, CURR HIV RES, V10, P620

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